Evaluation of the Efficiency of Treatment with Rituximab for Systemic Scleroderma (A Case Report)
The article describes a clinical case of a progressive form of systemic scleroderma in a 39-year-old man. The patient has an acute course and rapid progression of the disease with a significant initial decrease in the forced vital capacity of the lungs, with signs of an unfavorable prognosis, such a...
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| Format: | Article |
| Language: | Russian |
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SINAPS LLC
2021-01-01
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| Series: | Архивъ внутренней медицины |
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| Online Access: | https://www.medarhive.ru/jour/article/view/1123 |
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| author | E. N. Harlamova Ju. Ju. Karpenko |
| author_facet | E. N. Harlamova Ju. Ju. Karpenko |
| author_sort | E. N. Harlamova |
| collection | DOAJ |
| description | The article describes a clinical case of a progressive form of systemic scleroderma in a 39-year-old man. The patient has an acute course and rapid progression of the disease with a significant initial decrease in the forced vital capacity of the lungs, with signs of an unfavorable prognosis, such as a diffuse form, a high skin count (> 14), male sex, and high positivity for antibodies to Scl-70. In connection with the ineffectiveness of standard therapy with glucocorticoids and immunosuppressants at an early stage of the disease, the option of treatment with genetically engineered drugs (rituximab) was considered. As a result of the therapy, a positive trend was noted. |
| format | Article |
| id | doaj-art-de9899d4bee94701a5d851d618da4f9d |
| institution | DOAJ |
| issn | 2226-6704 2411-6564 |
| language | Russian |
| publishDate | 2021-01-01 |
| publisher | SINAPS LLC |
| record_format | Article |
| series | Архивъ внутренней медицины |
| spelling | doaj-art-de9899d4bee94701a5d851d618da4f9d2025-08-20T03:00:39ZrusSINAPS LLCАрхивъ внутренней медицины2226-67042411-65642021-01-01111727510.20514/2226-6704-2021-11-1-72-75829Evaluation of the Efficiency of Treatment with Rituximab for Systemic Scleroderma (A Case Report)E. N. Harlamova0Ju. Ju. Karpenko1State Budgetary Educational ln-stitution of High Professional Education «Voronezh State Medical University n.a. N.N. Burdenko» of the Ministry of Health of the Russian FederationState Budgetary Educational ln-stitution of High Professional Education «Voronezh State Medical University n.a. N.N. Burdenko» of the Ministry of Health of the Russian FederationThe article describes a clinical case of a progressive form of systemic scleroderma in a 39-year-old man. The patient has an acute course and rapid progression of the disease with a significant initial decrease in the forced vital capacity of the lungs, with signs of an unfavorable prognosis, such as a diffuse form, a high skin count (> 14), male sex, and high positivity for antibodies to Scl-70. In connection with the ineffectiveness of standard therapy with glucocorticoids and immunosuppressants at an early stage of the disease, the option of treatment with genetically engineered drugs (rituximab) was considered. As a result of the therapy, a positive trend was noted.https://www.medarhive.ru/jour/article/view/1123systemic sclerodermarituximabpoor prognosis |
| spellingShingle | E. N. Harlamova Ju. Ju. Karpenko Evaluation of the Efficiency of Treatment with Rituximab for Systemic Scleroderma (A Case Report) Архивъ внутренней медицины systemic scleroderma rituximab poor prognosis |
| title | Evaluation of the Efficiency of Treatment with Rituximab for Systemic Scleroderma (A Case Report) |
| title_full | Evaluation of the Efficiency of Treatment with Rituximab for Systemic Scleroderma (A Case Report) |
| title_fullStr | Evaluation of the Efficiency of Treatment with Rituximab for Systemic Scleroderma (A Case Report) |
| title_full_unstemmed | Evaluation of the Efficiency of Treatment with Rituximab for Systemic Scleroderma (A Case Report) |
| title_short | Evaluation of the Efficiency of Treatment with Rituximab for Systemic Scleroderma (A Case Report) |
| title_sort | evaluation of the efficiency of treatment with rituximab for systemic scleroderma a case report |
| topic | systemic scleroderma rituximab poor prognosis |
| url | https://www.medarhive.ru/jour/article/view/1123 |
| work_keys_str_mv | AT enharlamova evaluationoftheefficiencyoftreatmentwithrituximabforsystemicsclerodermaacasereport AT jujukarpenko evaluationoftheefficiencyoftreatmentwithrituximabforsystemicsclerodermaacasereport |