The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies
ABSTRACT Background and Aims Probiotics usually have beneficial effects on the absorption of trace elements and detoxification of toxic metals in human. Hence, the aim of the systematic review was to evaluate various aspects of the effect of the combination of probiotics and heavy metals in human cl...
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Wiley
2025-03-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70521 |
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| author | Atieh Darbandi Tahereh Navidifar Maryam Koupaei Roghayeh Afifirad Reyhaneh Amin Nezhad Amir Emamie Malihe Talebi Maryam Kakanj |
| author_facet | Atieh Darbandi Tahereh Navidifar Maryam Koupaei Roghayeh Afifirad Reyhaneh Amin Nezhad Amir Emamie Malihe Talebi Maryam Kakanj |
| author_sort | Atieh Darbandi |
| collection | DOAJ |
| description | ABSTRACT Background and Aims Probiotics usually have beneficial effects on the absorption of trace elements and detoxification of toxic metals in human. Hence, the aim of the systematic review was to evaluate various aspects of the effect of the combination of probiotics and heavy metals in human clinical trial studies. Methods Nine databases were searched for clinical trials up to June 2024 investigating probiotics for heavy metal exposure in humans. Two reviewers independently screened records and extracted data on study characteristics, interventions, outcomes, and results. Risk of bias was assessed. Results The analysis included 31 clinical trials with a total of 4,611 participants, focusing on the effects of probiotics, prebiotics, and synbiotics. Among the trials, 23 investigated probiotics, five looked at prebiotics, and three explored synbiotics, with probiotic doses ranging from 107 to 2.5 × 1010 CFU/day. Results indicated that probiotics combined with zinc significantly reduced the time to resolution of vomiting and diarrhea compared to zinc alone, improved the treatment efficacy of antibiotic‐associated diarrhea linked to pneumonia, and shortened hospital stays relative to probiotics alone. Probiotics did not show significant effects on blood parameters compared to placebo; however, prebiotic galactooligosaccharides enhanced iron absorption in women and children. The addition of probiotics to bismuth quadruple therapy did not improve Helicobacter pylori eradication rates but reduced side effects like diarrhea and vomiting. One trial reported a decrease in toxic metal levels in pregnant women due to probiotics, but no similar effects were observed in children. Conclusions Probiotics are one of the new methods employed to improve or eliminate the adverse effects of heavy metals in the body. Although many studies have investigated the effects of probiotics on heavy metals, there is still a need for more in‐depth and extensive studies. |
| format | Article |
| id | doaj-art-de94f3b2bbd34d9cb70bff10fd1f08d0 |
| institution | DOAJ |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-de94f3b2bbd34d9cb70bff10fd1f08d02025-08-20T02:54:30ZengWileyHealth Science Reports2398-88352025-03-0183n/an/a10.1002/hsr2.70521The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial StudiesAtieh Darbandi0Tahereh Navidifar1Maryam Koupaei2Roghayeh Afifirad3Reyhaneh Amin Nezhad4Amir Emamie5Malihe Talebi6Maryam Kakanj7Molecular Microbiology Research Center Shahed University Theran IranDepartment of Basic Sciences Shoushtar Faculty of Medical Sciences Shoushtar IranMolecular Microbiology Research Center Shahed University Theran IranDepartment of Microbiology, School of Medicine Tehran University of Medical Sciences Tehran IranDepartment of Microbiology, Faculty of Biological Sciences Alzahra University Tehran IranDepartment of Pathobiology, School of Public Health Tehran University of Medical Sciences Tehran IranMicrobial Biotechnology Research Centre Iran University of Medical Sciences Tehran IranFood and Drug Laboratory Research Center Food and Drug Administration, MOH&ME Tehran IranABSTRACT Background and Aims Probiotics usually have beneficial effects on the absorption of trace elements and detoxification of toxic metals in human. Hence, the aim of the systematic review was to evaluate various aspects of the effect of the combination of probiotics and heavy metals in human clinical trial studies. Methods Nine databases were searched for clinical trials up to June 2024 investigating probiotics for heavy metal exposure in humans. Two reviewers independently screened records and extracted data on study characteristics, interventions, outcomes, and results. Risk of bias was assessed. Results The analysis included 31 clinical trials with a total of 4,611 participants, focusing on the effects of probiotics, prebiotics, and synbiotics. Among the trials, 23 investigated probiotics, five looked at prebiotics, and three explored synbiotics, with probiotic doses ranging from 107 to 2.5 × 1010 CFU/day. Results indicated that probiotics combined with zinc significantly reduced the time to resolution of vomiting and diarrhea compared to zinc alone, improved the treatment efficacy of antibiotic‐associated diarrhea linked to pneumonia, and shortened hospital stays relative to probiotics alone. Probiotics did not show significant effects on blood parameters compared to placebo; however, prebiotic galactooligosaccharides enhanced iron absorption in women and children. The addition of probiotics to bismuth quadruple therapy did not improve Helicobacter pylori eradication rates but reduced side effects like diarrhea and vomiting. One trial reported a decrease in toxic metal levels in pregnant women due to probiotics, but no similar effects were observed in children. Conclusions Probiotics are one of the new methods employed to improve or eliminate the adverse effects of heavy metals in the body. Although many studies have investigated the effects of probiotics on heavy metals, there is still a need for more in‐depth and extensive studies.https://doi.org/10.1002/hsr2.70521detoxificationdiarrheaheavy metalsiron deficiencyprobiotics |
| spellingShingle | Atieh Darbandi Tahereh Navidifar Maryam Koupaei Roghayeh Afifirad Reyhaneh Amin Nezhad Amir Emamie Malihe Talebi Maryam Kakanj The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies Health Science Reports detoxification diarrhea heavy metals iron deficiency probiotics |
| title | The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies |
| title_full | The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies |
| title_fullStr | The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies |
| title_full_unstemmed | The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies |
| title_short | The Effect of the Combination of Probiotics and Heavy Metals From Various Aspects in Humans: A Systematic Review of Clinical Trial Studies |
| title_sort | effect of the combination of probiotics and heavy metals from various aspects in humans a systematic review of clinical trial studies |
| topic | detoxification diarrhea heavy metals iron deficiency probiotics |
| url | https://doi.org/10.1002/hsr2.70521 |
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