Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases
Microglia-mediated neuroinflammation is one of the most remarkable hallmarks of neurodegenerative diseases (NDDs), including AD, PD, and ALS. Accumulating evidence indicates that microglia play both neuroprotective and detrimental roles in the onset and progression of NDDs. Yet, the specific mechani...
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| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/9912686 |
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| author | Li Wang Chao-Chao Yu Xin-Yuan Liu Xiao-Ni Deng Qing Tian Yan-Jun Du |
| author_facet | Li Wang Chao-Chao Yu Xin-Yuan Liu Xiao-Ni Deng Qing Tian Yan-Jun Du |
| author_sort | Li Wang |
| collection | DOAJ |
| description | Microglia-mediated neuroinflammation is one of the most remarkable hallmarks of neurodegenerative diseases (NDDs), including AD, PD, and ALS. Accumulating evidence indicates that microglia play both neuroprotective and detrimental roles in the onset and progression of NDDs. Yet, the specific mechanisms of action surrounding microglia are not clear. Modulation of microglia function and phenotypes appears to be a potential strategy to reverse NDDs. Until recently, research into the epigenetic mechanisms of diseases has been gradually developed, making it possible to elucidate the molecular mechanisms underlying the epigenetic regulation of microglia in NDDs. This review highlights the function and phenotypes of microglia, elucidates the relationship between microglia, epigenetic modifications, and NDDs, as well as the possible mechanisms underlying the epigenetic modulation of microglia in NDDs with a focus on potential intervention strategies. |
| format | Article |
| id | doaj-art-de911a00256a47f4b43467d4facab03e |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-de911a00256a47f4b43467d4facab03e2025-02-03T01:20:37ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/99126869912686Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative DiseasesLi Wang0Chao-Chao Yu1Xin-Yuan Liu2Xiao-Ni Deng3Qing Tian4Yan-Jun Du5College of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, ChinaDepartment of Tuina, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, ChinaCollege of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, ChinaCollege of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, ChinaDepartment of Pathology and Pathophysiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, ChinaCollege of Acupuncture and Orthopedics, Hubei University of Chinese Medicine, Wuhan, Hubei, ChinaMicroglia-mediated neuroinflammation is one of the most remarkable hallmarks of neurodegenerative diseases (NDDs), including AD, PD, and ALS. Accumulating evidence indicates that microglia play both neuroprotective and detrimental roles in the onset and progression of NDDs. Yet, the specific mechanisms of action surrounding microglia are not clear. Modulation of microglia function and phenotypes appears to be a potential strategy to reverse NDDs. Until recently, research into the epigenetic mechanisms of diseases has been gradually developed, making it possible to elucidate the molecular mechanisms underlying the epigenetic regulation of microglia in NDDs. This review highlights the function and phenotypes of microglia, elucidates the relationship between microglia, epigenetic modifications, and NDDs, as well as the possible mechanisms underlying the epigenetic modulation of microglia in NDDs with a focus on potential intervention strategies.http://dx.doi.org/10.1155/2021/9912686 |
| spellingShingle | Li Wang Chao-Chao Yu Xin-Yuan Liu Xiao-Ni Deng Qing Tian Yan-Jun Du Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases Neural Plasticity |
| title | Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases |
| title_full | Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases |
| title_fullStr | Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases |
| title_full_unstemmed | Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases |
| title_short | Epigenetic Modulation of Microglia Function and Phenotypes in Neurodegenerative Diseases |
| title_sort | epigenetic modulation of microglia function and phenotypes in neurodegenerative diseases |
| url | http://dx.doi.org/10.1155/2021/9912686 |
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