The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study
Aphasia in bilingual patients is a therapeutic challenge since both languages can be impacted by the same lesion. Language control has been suggested to play an important role in the recovery of first (L1) and second (L2) language in bilingual aphasia following stroke. To test this hypothesis, we co...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2016/8797086 |
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| author | Narges Radman Michael Mouthon Marie Di Pietro Chrisovalandou Gaytanidis Beatrice Leemann Jubin Abutalebi Jean-Marie Annoni |
| author_facet | Narges Radman Michael Mouthon Marie Di Pietro Chrisovalandou Gaytanidis Beatrice Leemann Jubin Abutalebi Jean-Marie Annoni |
| author_sort | Narges Radman |
| collection | DOAJ |
| description | Aphasia in bilingual patients is a therapeutic challenge since both languages can be impacted by the same lesion. Language control has been suggested to play an important role in the recovery of first (L1) and second (L2) language in bilingual aphasia following stroke. To test this hypothesis, we collected behavioral measures of language production (general aphasia evaluation and picture naming) in each language and language control (linguistic and nonlinguistic switching tasks), as well as fMRI during a naming task at one and four months following stroke in five bilingual patients suffering from poststroke aphasia. We further applied dynamic causal modelling (DCM) analyses to the connections between language and control brain areas. Three patients showed parallel recovery in language production, one patient improved in L1, and one improved in L2 only. Language-control functions improved in two patients. Consistent with the dynamic view of language recovery, DCM analyses showed a higher connectedness between language and control areas in the language with the better recovery. Moreover, similar degrees of connectedness between language and control areas were found in the patients who recovered in both languages. Our data suggest that engagement of the interconnected language-control network is crucial in the recovery of languages. |
| format | Article |
| id | doaj-art-de9017b2daac4e4da990670044b8124f |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-de9017b2daac4e4da990670044b8124f2025-02-03T01:22:02ZengWileyNeural Plasticity2090-59041687-54432016-01-01201610.1155/2016/87970868797086The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI StudyNarges Radman0Michael Mouthon1Marie Di Pietro2Chrisovalandou Gaytanidis3Beatrice Leemann4Jubin Abutalebi5Jean-Marie Annoni6Neurology Unit, Department of Medicine, Faculty of Sciences, University of Fribourg, Fribourg, SwitzerlandNeurology Unit, Department of Medicine, Faculty of Sciences, University of Fribourg, Fribourg, SwitzerlandNeurorehabilitation Department, University Hospital, University of Geneva, Geneva, SwitzerlandNeurorehabilitation Department, University Hospital, University of Geneva, Geneva, SwitzerlandNeurorehabilitation Department, University Hospital, University of Geneva, Geneva, SwitzerlandCenter for Neurolinguistics and Psycholinguistics, San Raffaele University and Scientific Institute San Raffaele, Milan, ItalyNeurology Unit, Department of Medicine, Faculty of Sciences, University of Fribourg, Fribourg, SwitzerlandAphasia in bilingual patients is a therapeutic challenge since both languages can be impacted by the same lesion. Language control has been suggested to play an important role in the recovery of first (L1) and second (L2) language in bilingual aphasia following stroke. To test this hypothesis, we collected behavioral measures of language production (general aphasia evaluation and picture naming) in each language and language control (linguistic and nonlinguistic switching tasks), as well as fMRI during a naming task at one and four months following stroke in five bilingual patients suffering from poststroke aphasia. We further applied dynamic causal modelling (DCM) analyses to the connections between language and control brain areas. Three patients showed parallel recovery in language production, one patient improved in L1, and one improved in L2 only. Language-control functions improved in two patients. Consistent with the dynamic view of language recovery, DCM analyses showed a higher connectedness between language and control areas in the language with the better recovery. Moreover, similar degrees of connectedness between language and control areas were found in the patients who recovered in both languages. Our data suggest that engagement of the interconnected language-control network is crucial in the recovery of languages.http://dx.doi.org/10.1155/2016/8797086 |
| spellingShingle | Narges Radman Michael Mouthon Marie Di Pietro Chrisovalandou Gaytanidis Beatrice Leemann Jubin Abutalebi Jean-Marie Annoni The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study Neural Plasticity |
| title | The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study |
| title_full | The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study |
| title_fullStr | The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study |
| title_full_unstemmed | The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study |
| title_short | The Role of the Cognitive Control System in Recovery from Bilingual Aphasia: A Multiple Single-Case fMRI Study |
| title_sort | role of the cognitive control system in recovery from bilingual aphasia a multiple single case fmri study |
| url | http://dx.doi.org/10.1155/2016/8797086 |
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