Reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophrenia
Abstract Aim Schizophrenia (SZ) is characterized by abnormalities in self‐representation, including an aberrant sense of agency (SoA). Experimentally observed abnormalities in force matching and intentional binding tasks suggest that the SoA in SZ is compromised at the implicit level. However, these...
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Wiley
2025-06-01
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| Series: | PCN Reports |
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| Online Access: | https://doi.org/10.1002/pcn5.70106 |
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| author | Akihiro Koreki Yuri Terasawa Hiroki Oi Takuya Mouri Aki Takenaka Teruki Koizumi Mitsumoto Onaya Mahinda Yogarajah Hugo Critchley Atsuo Nuruki |
| author_facet | Akihiro Koreki Yuri Terasawa Hiroki Oi Takuya Mouri Aki Takenaka Teruki Koizumi Mitsumoto Onaya Mahinda Yogarajah Hugo Critchley Atsuo Nuruki |
| author_sort | Akihiro Koreki |
| collection | DOAJ |
| description | Abstract Aim Schizophrenia (SZ) is characterized by abnormalities in self‐representation, including an aberrant sense of agency (SoA). Experimentally observed abnormalities in force matching and intentional binding tasks suggest that the SoA in SZ is compromised at the implicit level. However, these task effects have been reported independently, leading to inconsistencies that complicate the understanding of SZ pathophysiology. Methods Thirty‐three patients with SZ and 37 nonclinical (healthy) controls (HCs) performed force matching and intentional binding tasks. The former task assessed sensory attenuation, while the latter evaluated an intentional binding effect, both measuring implicit levels of SoA. We previously observed that the cardiac phase (systole vs diastole) influences intentional binding. Therefore, we investigated the relationship between sensory attenuation and intentional binding, including this “cardiac effect,” which refers to the influence of cardiac interoceptive signals. Results In SZ, significantly reduced sensory attenuation, a greater but nonsignificant intentional binding effect, and a significant opposite cardiac effect were observed compared with HCs. Sensory attenuation and intentional binding were significantly and positively correlated in the SZ group but not in the HC group. Across all participants, sensory attenuation correlated with the cardiac effect on intentional binding. This effect remained significant in the HC group but not in the SZ group. Conclusion Group differences and task associations suggest shared mechanisms and pathophysiology in SZ, potentially involving impaired predictive processes and the failure of sensory attenuation. The cardiac effect may be explained by interoceptive sensory attenuation, and its failure could lead to a disturbed SoA in patients with SZ. |
| format | Article |
| id | doaj-art-de8cb130801c412bb3064c2219fce7e4 |
| institution | Kabale University |
| issn | 2769-2558 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Wiley |
| record_format | Article |
| series | PCN Reports |
| spelling | doaj-art-de8cb130801c412bb3064c2219fce7e42025-08-20T03:27:57ZengWileyPCN Reports2769-25582025-06-0142n/an/a10.1002/pcn5.70106Reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophreniaAkihiro Koreki0Yuri Terasawa1Hiroki Oi2Takuya Mouri3Aki Takenaka4Teruki Koizumi5Mitsumoto Onaya6Mahinda Yogarajah7Hugo Critchley8Atsuo Nuruki9Department of Psychiatry NHO Shimofusa Psychiatric Medical Center Chiba JapanDepartment of Psychology Keio University Tokyo JapanDepartment of Neuropsychiatry Keio University School of Medicine Tokyo JapanCenter for General Education, Institute for Comprehensive Education Kagoshima University Kagoshima JapanCenter for General Education, Institute for Comprehensive Education Kagoshima University Kagoshima JapanDepartment of Psychiatry NHO Shimofusa Psychiatric Medical Center Chiba JapanDepartment of Psychiatry NHO Shimofusa Psychiatric Medical Center Chiba JapanDepartment of Clinical & Experimental Epilepsy UCL Queen Square Institute of Neurology London UKDepartment of Clinical Neuroscience Brighton and Sussex Medical School, Sussex University Brighton UKCenter for General Education, Institute for Comprehensive Education Kagoshima University Kagoshima JapanAbstract Aim Schizophrenia (SZ) is characterized by abnormalities in self‐representation, including an aberrant sense of agency (SoA). Experimentally observed abnormalities in force matching and intentional binding tasks suggest that the SoA in SZ is compromised at the implicit level. However, these task effects have been reported independently, leading to inconsistencies that complicate the understanding of SZ pathophysiology. Methods Thirty‐three patients with SZ and 37 nonclinical (healthy) controls (HCs) performed force matching and intentional binding tasks. The former task assessed sensory attenuation, while the latter evaluated an intentional binding effect, both measuring implicit levels of SoA. We previously observed that the cardiac phase (systole vs diastole) influences intentional binding. Therefore, we investigated the relationship between sensory attenuation and intentional binding, including this “cardiac effect,” which refers to the influence of cardiac interoceptive signals. Results In SZ, significantly reduced sensory attenuation, a greater but nonsignificant intentional binding effect, and a significant opposite cardiac effect were observed compared with HCs. Sensory attenuation and intentional binding were significantly and positively correlated in the SZ group but not in the HC group. Across all participants, sensory attenuation correlated with the cardiac effect on intentional binding. This effect remained significant in the HC group but not in the SZ group. Conclusion Group differences and task associations suggest shared mechanisms and pathophysiology in SZ, potentially involving impaired predictive processes and the failure of sensory attenuation. The cardiac effect may be explained by interoceptive sensory attenuation, and its failure could lead to a disturbed SoA in patients with SZ.https://doi.org/10.1002/pcn5.70106interoceptionschizophreniaselfsense of agencysensory attenuation |
| spellingShingle | Akihiro Koreki Yuri Terasawa Hiroki Oi Takuya Mouri Aki Takenaka Teruki Koizumi Mitsumoto Onaya Mahinda Yogarajah Hugo Critchley Atsuo Nuruki Reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophrenia PCN Reports interoception schizophrenia self sense of agency sensory attenuation |
| title | Reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophrenia |
| title_full | Reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophrenia |
| title_fullStr | Reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophrenia |
| title_full_unstemmed | Reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophrenia |
| title_short | Reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophrenia |
| title_sort | reduced sensory attenuation is related to aberrant interoceptive influences on intentional binding in schizophrenia |
| topic | interoception schizophrenia self sense of agency sensory attenuation |
| url | https://doi.org/10.1002/pcn5.70106 |
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