Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study
Diffuse large B cell lymphoma is the most common type of lymphoma in Egypt with an unfavorable prognosis. The tumor microenvironment is rich in immune response either T cells or macrophages. The current study is aimed at testing CD4, CD8, CD68, and MMP9 immunohistochemistry of DLBCL activities with...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2022-01-01
|
| Series: | Analytical Cellular Pathology |
| Online Access: | http://dx.doi.org/10.1155/2022/9993496 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849467323961835520 |
|---|---|
| author | Doaa Shams-Deen Ghorab Ahmed Mohamed Helaly Hoda Saleh El Mahdi Moawiah Khatatbeh Afaf Taha Ibrahiem |
| author_facet | Doaa Shams-Deen Ghorab Ahmed Mohamed Helaly Hoda Saleh El Mahdi Moawiah Khatatbeh Afaf Taha Ibrahiem |
| author_sort | Doaa Shams-Deen Ghorab |
| collection | DOAJ |
| description | Diffuse large B cell lymphoma is the most common type of lymphoma in Egypt with an unfavorable prognosis. The tumor microenvironment is rich in immune response either T cells or macrophages. The current study is aimed at testing CD4, CD8, CD68, and MMP9 immunohistochemistry of DLBCL activities with the prognosis of the tumor. The results showed no positive relation between T cell and macrophage reaction to the tumor prognosis suggesting that this reaction is part of the tumor process and not a defense mechanism from the surrounding stroma. |
| format | Article |
| id | doaj-art-de7e00ff74e445a09550e152443e1c03 |
| institution | Kabale University |
| issn | 2210-7185 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Analytical Cellular Pathology |
| spelling | doaj-art-de7e00ff74e445a09550e152443e1c032025-08-20T03:26:16ZengWileyAnalytical Cellular Pathology2210-71852022-01-01202210.1155/2022/9993496Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical StudyDoaa Shams-Deen Ghorab0Ahmed Mohamed Helaly1Hoda Saleh El Mahdi2Moawiah Khatatbeh3Afaf Taha Ibrahiem4Pathology DepartmentForensic and Clinical Toxicology DepartmentPathology DepartmentBasic DepartmentPathology DepartmentDiffuse large B cell lymphoma is the most common type of lymphoma in Egypt with an unfavorable prognosis. The tumor microenvironment is rich in immune response either T cells or macrophages. The current study is aimed at testing CD4, CD8, CD68, and MMP9 immunohistochemistry of DLBCL activities with the prognosis of the tumor. The results showed no positive relation between T cell and macrophage reaction to the tumor prognosis suggesting that this reaction is part of the tumor process and not a defense mechanism from the surrounding stroma.http://dx.doi.org/10.1155/2022/9993496 |
| spellingShingle | Doaa Shams-Deen Ghorab Ahmed Mohamed Helaly Hoda Saleh El Mahdi Moawiah Khatatbeh Afaf Taha Ibrahiem Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study Analytical Cellular Pathology |
| title | Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study |
| title_full | Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study |
| title_fullStr | Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study |
| title_full_unstemmed | Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study |
| title_short | Prognostic Role of Tumor Microenvironment in DLBCL and Relation to Patients’ Clinical Outcome: A Clinical and Immunohistochemical Study |
| title_sort | prognostic role of tumor microenvironment in dlbcl and relation to patients clinical outcome a clinical and immunohistochemical study |
| url | http://dx.doi.org/10.1155/2022/9993496 |
| work_keys_str_mv | AT doaashamsdeenghorab prognosticroleoftumormicroenvironmentindlbclandrelationtopatientsclinicaloutcomeaclinicalandimmunohistochemicalstudy AT ahmedmohamedhelaly prognosticroleoftumormicroenvironmentindlbclandrelationtopatientsclinicaloutcomeaclinicalandimmunohistochemicalstudy AT hodasalehelmahdi prognosticroleoftumormicroenvironmentindlbclandrelationtopatientsclinicaloutcomeaclinicalandimmunohistochemicalstudy AT moawiahkhatatbeh prognosticroleoftumormicroenvironmentindlbclandrelationtopatientsclinicaloutcomeaclinicalandimmunohistochemicalstudy AT afaftahaibrahiem prognosticroleoftumormicroenvironmentindlbclandrelationtopatientsclinicaloutcomeaclinicalandimmunohistochemicalstudy |