A Comprehensive Review on <i>Graptopetalum paraguayense</i>’s Phytochemical Profiles, Pharmacological Activities, and Development as a Functional Food
<i>Graptopetalum paraguayense</i> (<i>G. paraguayense</i>) is a succulent plant that has been used in traditional Chinese and Taiwanese medicine, mainly for antihypertensive and hepatoprotective activities. <i>G. paraguayense</i> is also used as an edible vegetabl...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2025-01-01
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| Series: | Plants |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2223-7747/14/3/349 |
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| Summary: | <i>Graptopetalum paraguayense</i> (<i>G. paraguayense</i>) is a succulent plant that has been used in traditional Chinese and Taiwanese medicine, mainly for antihypertensive and hepatoprotective activities. <i>G. paraguayense</i> is also used as an edible vegetable, which is considered a functional food. Different in vitro, in vivo, and clinical studies have highlighted the multiple pharmacological activities of <i>G. paraguayense</i>, which include anticancer, antibacterial, antiviral, antiasthma, antihypertensive, skin-whitening and anti-aging, anti-Alzheimer, neuroprotective, and hepatoprotective activities. Numerous studies revealed the antioxidant and anti-inflammatory potential of <i>G. paraguayense,</i> which may be the major contributing factor for multiple pharmacological activities and the protective effect of <i>G. paraguayense</i> on pancreatic, liver, lung, colon, and brain diseases. Initial safety studies on animal models also support the therapeutic candidature of <i>G. paraguayense</i>. The presence of numerous bioactive phytochemicals, especially polyphenols, and the identification of important disease targets of <i>G. paraguayense</i> emphasize its high therapeutic potential. The lack of a directional approach and limited in vivo studies limit the development of <i>G. paraguayense</i> against important diseases. Still, a compilation of pharmacological activities and target pathways of <i>G. paraguayense</i> is missing in the literature. The current review not only compiles pharmacological activities and phytochemicals but also highlights gaps and proposes future directions for developing <i>G. paraguayense</i> as a candidate against important diseases. |
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| ISSN: | 2223-7747 |