Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus
The cholinergic system plays a fundamental role in learning and memory. Pharmacological activation of the muscarinic receptor M1R potentiates NMDA receptor activity and induces short-term potentiation at the synapses called muscarinic LTP, mLTP. Dysfunction of cholinergic transmission has been detec...
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Neural Plasticity |
| Online Access: | http://dx.doi.org/10.1155/2021/8813734 |
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| author | Efrat Shavit-Stein Amir Dori Marina Ben Shimon Shany Guly Gofrit Nicola Maggio |
| author_facet | Efrat Shavit-Stein Amir Dori Marina Ben Shimon Shany Guly Gofrit Nicola Maggio |
| author_sort | Efrat Shavit-Stein |
| collection | DOAJ |
| description | The cholinergic system plays a fundamental role in learning and memory. Pharmacological activation of the muscarinic receptor M1R potentiates NMDA receptor activity and induces short-term potentiation at the synapses called muscarinic LTP, mLTP. Dysfunction of cholinergic transmission has been detected in the settings of cognitive impairment and dementia. Systemic inflammation as well as neuroinflammation has been shown to profoundly alter synaptic transmission and LTP. Indeed, intervention which is aimed at reducing neuroinflammatory changes in the brain has been associated with an improvement in cognitive functions. While cognitive impairment caused either by cholinergic dysfunction and/or by systemic inflammation suggests a possible connection between the two, so far whether systemic inflammation affects mLTP has not been extensively studied. In the present work, we explored whether an acute versus persistent systemic inflammation induced by LPS injections would differently affect the ability of hippocampal synapses to undergo mLTP. Interestingly, while a short exposure to LPS resulted in a transient deficit in mLTP expression, a longer exposure persistently impaired mLTP. We believe that these findings may be involved in cognitive dysfunctions following sepsis and possibly neuroinflammatory processes. |
| format | Article |
| id | doaj-art-de7b22c9b8fb4ef7a728bf02f08adcdf |
| institution | Kabale University |
| issn | 2090-5904 1687-5443 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Neural Plasticity |
| spelling | doaj-art-de7b22c9b8fb4ef7a728bf02f08adcdf2025-08-20T03:26:16ZengWileyNeural Plasticity2090-59041687-54432021-01-01202110.1155/2021/88137348813734Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the HippocampusEfrat Shavit-Stein0Amir Dori1Marina Ben Shimon2Shany Guly Gofrit3Nicola Maggio4Department of Neurology, The Chaim Sheba Medical Center, Ramat Gan, 52621 Tel HaShomer, IsraelDepartment of Neurology, The Chaim Sheba Medical Center, Ramat Gan, 52621 Tel HaShomer, IsraelDepartment of Neurology, The Chaim Sheba Medical Center, Ramat Gan, 52621 Tel HaShomer, IsraelDepartment of Neurology, The Chaim Sheba Medical Center, Ramat Gan, 52621 Tel HaShomer, IsraelDepartment of Neurology, The Chaim Sheba Medical Center, Ramat Gan, 52621 Tel HaShomer, IsraelThe cholinergic system plays a fundamental role in learning and memory. Pharmacological activation of the muscarinic receptor M1R potentiates NMDA receptor activity and induces short-term potentiation at the synapses called muscarinic LTP, mLTP. Dysfunction of cholinergic transmission has been detected in the settings of cognitive impairment and dementia. Systemic inflammation as well as neuroinflammation has been shown to profoundly alter synaptic transmission and LTP. Indeed, intervention which is aimed at reducing neuroinflammatory changes in the brain has been associated with an improvement in cognitive functions. While cognitive impairment caused either by cholinergic dysfunction and/or by systemic inflammation suggests a possible connection between the two, so far whether systemic inflammation affects mLTP has not been extensively studied. In the present work, we explored whether an acute versus persistent systemic inflammation induced by LPS injections would differently affect the ability of hippocampal synapses to undergo mLTP. Interestingly, while a short exposure to LPS resulted in a transient deficit in mLTP expression, a longer exposure persistently impaired mLTP. We believe that these findings may be involved in cognitive dysfunctions following sepsis and possibly neuroinflammatory processes.http://dx.doi.org/10.1155/2021/8813734 |
| spellingShingle | Efrat Shavit-Stein Amir Dori Marina Ben Shimon Shany Guly Gofrit Nicola Maggio Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus Neural Plasticity |
| title | Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus |
| title_full | Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus |
| title_fullStr | Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus |
| title_full_unstemmed | Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus |
| title_short | Prolonged Systemic Inflammation Alters Muscarinic Long-Term Potentiation (mLTP) in the Hippocampus |
| title_sort | prolonged systemic inflammation alters muscarinic long term potentiation mltp in the hippocampus |
| url | http://dx.doi.org/10.1155/2021/8813734 |
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