Dissecting small cell carcinoma of the esophagus ecosystem by single-cell transcriptomic analysis

Dissecting small cell carcinoma of the esophagus ecosystem by single-cell transcriptomic analysis

Abstract Small cell carcinoma of the esophagus (SCCE) is an aggressive and rare neuroendocrine malignancy with poor prognosis. Here, we firstly performed single-cell transcriptional profiling derived from 10 SCCE patients, with normal esophageal mucosa, adjacent non-malignant tissue and tumors from...

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Main Authors: Hao-Xiang Wu, Yu-Kun Chen, Ying-Nan Wang, Jia-Ying Chen, Shu-Jing Xiang, Ying Jin, Zi-Xian Wang, Chun-Yu Huang, Lu-Ping Yang, Ye He, Wen-Long Guan, Long Bai, Yan-Xing Chen, Min Wang, Chao-Ye Wang, Run-Jie Huang, Yue Huang, Jin-Ling Zhang, Zhi-Da Lv, Si-Qi Yang, Rui-Hua Xu, Qi Zhao, Feng Wang
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Molecular Cancer
Online Access:https://doi.org/10.1186/s12943-025-02335-5
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