Fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopenia
Dermatophytic pseudomycetoma is a rare invasive infection, involving both immunocompetent and immunocompromised individuals. Since the discovery of inherited immune disorders such as the impairment of CARD9 gene, extended dermatophyte infections are mostly ascribed to any of these host factors. This...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Emerging Microbes and Infections |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/22221751.2023.2208685 |
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| author | Yinggai Song Xiaowen Wang Qian Li Ruijun Zhang Sybren de Hoog Ruoyu Li |
| author_facet | Yinggai Song Xiaowen Wang Qian Li Ruijun Zhang Sybren de Hoog Ruoyu Li |
| author_sort | Yinggai Song |
| collection | DOAJ |
| description | Dermatophytic pseudomycetoma is a rare invasive infection, involving both immunocompetent and immunocompromised individuals. Since the discovery of inherited immune disorders such as the impairment of CARD9 gene, extended dermatophyte infections are mostly ascribed to any of these host factors. This study is to present and explore the potential causes in a fatal dermatophytic pseudomycetoma patient. We present a chronic and deep pseudomycetoma caused by the common dermatophyte Microsporum canis which ultimately led to the death of the patient. Mycological examination, genetic studies and host immune responses against fungi were performed to explore the potential factors. The patient had decreased lymphocyte counts with significantly reduced CD4+ T cells, although all currently known genetic parameters proved to be normal. Through functional studies, we demonstrated that peripheral blood mononuclear cells from the patient showed severe impairment of adaptive cytokine production upon fungus-specific stimulation, whereas innate immune responses were partially defective. This is, to our knowledge, the first report of fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopenia, which highlights the importance of screening for immune deficiencies in patients with deep dermatophytosis. |
| format | Article |
| id | doaj-art-de751f3229ae482d91083ac369ea60b2 |
| institution | Kabale University |
| issn | 2222-1751 |
| language | English |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Emerging Microbes and Infections |
| spelling | doaj-art-de751f3229ae482d91083ac369ea60b22025-08-20T03:52:57ZengTaylor & Francis GroupEmerging Microbes and Infections2222-17512023-12-0112110.1080/22221751.2023.2208685Fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopeniaYinggai Song0Xiaowen Wang1Qian Li2Ruijun Zhang3Sybren de Hoog4Ruoyu Li5Department of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of ChinaDepartment of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of ChinaDepartment of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of ChinaDepartment of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of ChinaDepartment of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of ChinaDepartment of Dermatology and Venerology, Peking University First Hospital, Beijing, People’s Republic of ChinaDermatophytic pseudomycetoma is a rare invasive infection, involving both immunocompetent and immunocompromised individuals. Since the discovery of inherited immune disorders such as the impairment of CARD9 gene, extended dermatophyte infections are mostly ascribed to any of these host factors. This study is to present and explore the potential causes in a fatal dermatophytic pseudomycetoma patient. We present a chronic and deep pseudomycetoma caused by the common dermatophyte Microsporum canis which ultimately led to the death of the patient. Mycological examination, genetic studies and host immune responses against fungi were performed to explore the potential factors. The patient had decreased lymphocyte counts with significantly reduced CD4+ T cells, although all currently known genetic parameters proved to be normal. Through functional studies, we demonstrated that peripheral blood mononuclear cells from the patient showed severe impairment of adaptive cytokine production upon fungus-specific stimulation, whereas innate immune responses were partially defective. This is, to our knowledge, the first report of fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopenia, which highlights the importance of screening for immune deficiencies in patients with deep dermatophytosis.https://www.tandfonline.com/doi/10.1080/22221751.2023.2208685Dermatophytepseudomycetomafatal infectionnon-HIV CD4 lymphocytopeniaMicrosporum canis |
| spellingShingle | Yinggai Song Xiaowen Wang Qian Li Ruijun Zhang Sybren de Hoog Ruoyu Li Fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopenia Emerging Microbes and Infections Dermatophyte pseudomycetoma fatal infection non-HIV CD4 lymphocytopenia Microsporum canis |
| title | Fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopenia |
| title_full | Fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopenia |
| title_fullStr | Fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopenia |
| title_full_unstemmed | Fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopenia |
| title_short | Fatal dermatophytic pseudomycetoma in a patient with non-HIV CD4 lymphocytopenia |
| title_sort | fatal dermatophytic pseudomycetoma in a patient with non hiv cd4 lymphocytopenia |
| topic | Dermatophyte pseudomycetoma fatal infection non-HIV CD4 lymphocytopenia Microsporum canis |
| url | https://www.tandfonline.com/doi/10.1080/22221751.2023.2208685 |
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