Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver

Effects of Chronic Alcohol Intake on the Composition of the Ensemble of Drug-Metabolizing Enzymes and Transporters in the Human Liver

In this study, to better understand the mechanisms of the profound impact of alcohol consumption on drug pharmacokinetics, efficacy, and toxicity, we characterized the alcohol-induced changes in the ensemble of drug-metabolizing enzymes and transporters (DMETs) in the human liver by performing globa...

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Bibliographic Details
Main Authors: Kari A. Gaither, Guihua Yue, Dilip Kumar Singh, Julia Trudeau, Kannapiran Ponraj, Nadezhda Y. Davydova, Philip Lazarus, Dmitri R. Davydov, Bhagwat Prasad
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Journal of Xenobiotics
Subjects:
drug metabolism
human liver microsomes
cytochromes P450
alcohol consumption
tobacco smoking
proteomics
Online Access:https://www.mdpi.com/2039-4713/15/1/20
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