A New Combination of <i>Bifidobacterium bifidum</i> and <i>Lactococcus lactis</i> Strains with Synergistic Effects Alleviates Colitis-Associated Colorectal Cancer

A New Combination of <i>Bifidobacterium bifidum</i> and <i>Lactococcus lactis</i> Strains with Synergistic Effects Alleviates Colitis-Associated Colorectal Cancer

Chronic inflammation is a factor in the development of cancer, and probiotics play a role in preventing or treating inflammation as an adjuvant therapy. To investigate potential probiotics for the prevention of colitis-associated colorectal cancer (CAC), <i>Bifidobacterium bifidum</i> H3...

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Bibliographic Details
Main Authors: Jiacui Shang, Lijun Liu, Shuo Yang, Bofan Duan, Shuiqi Xie, Xiangchen Meng
Format: Article
Language:English
Published: MDPI AG 2024-09-01
Series:Foods
Subjects:
probiotics
chronic inflammation
tight junction protein
gut microbiota
Online Access:https://www.mdpi.com/2304-8158/13/19/3054
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Summary:Chronic inflammation is a factor in the development of cancer, and probiotics play a role in preventing or treating inflammation as an adjuvant therapy. To investigate potential probiotics for the prevention of colitis-associated colorectal cancer (CAC), <i>Bifidobacterium bifidum</i> H3-R2 and <i>Lactococcus lactis</i> KLDS4.0325 were used to examine the effects on colon cancer cells and in an inflammation-related cancer animal model. The results revealed that <i>B. bifidum</i> H3-R2 in combination with <i>L. lactis</i> KLDS4.0325 caused apoptosis in colon cancer cells by increasing caspase-3 and caspase-9 protein levels, enhancing Bax expression, and lowering Bcl-2 expression. In addition, the combination of the two strains relieved the tissue damage; reduced proinflammatory cytokines, myeloperoxidase (MPO) activity, and hypoxia-inducible factor 1-alpha (HIF-1α) level; upregulated anti-inflammatory cytokines; increased colonic tight junction protein expression; regulated intestinal homeostasis by inhibiting NLRP3 inflammasome signaling pathway; and improved the imbalance of gut microbiota in animal models. Moreover, the combination of the two strains had a greater preventive impact than each strain alone. These findings are supportive of clinical studies and product development of multi-strain probiotic preparations for diseases associated with colitis.
ISSN:2304-8158

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