Circulating serum amyloid A levels but not SAA1 variants predict long-term outcomes of angiographically confirmed coronary artery disease
Objectives: Circulating serum amyloid A (SAA) levels are strongly associated with atherosclerotic cardiovascular disease risk and severity. The association between SAA1 genetic variants, SAA levels, inflammatory marker levels, and coronary artery disease (CAD) prognosis has not been fully understood...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
| Series: | Tzu Chi Medical Journal |
| Subjects: | |
| Online Access: | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=4;spage=423;epage=433;aulast=Yeh |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849324735144394752 |
|---|---|
| author | Kuan-Hung Yeh Lung-An Hsu Jyh-Ming Jimmy Juang Fu-Tien Chiang Ming-Sheng Teng I-Shiang Tzeng Semon Wu Jeng-Feng Lin Yu-Lin Ko |
| author_facet | Kuan-Hung Yeh Lung-An Hsu Jyh-Ming Jimmy Juang Fu-Tien Chiang Ming-Sheng Teng I-Shiang Tzeng Semon Wu Jeng-Feng Lin Yu-Lin Ko |
| author_sort | Kuan-Hung Yeh |
| collection | DOAJ |
| description | Objectives: Circulating serum amyloid A (SAA) levels are strongly associated with atherosclerotic cardiovascular disease risk and severity. The association between SAA1 genetic variants, SAA levels, inflammatory marker levels, and coronary artery disease (CAD) prognosis has not been fully understood. Materials and Methods: In total, 2199 Taiwan Biobank (TWB) participants were enrolled for a genome-wide association study (GWAS), and the long-term outcomes in 481 patients with CAD were analyzed. The primary endpoint was all-cause mortality, and the secondary endpoint was the combination of all-cause death, myocardial infarction, stroke, and hospitalization for heart failure. Results: Through GWAS, SAA1 rs11024600 and rs7112278 were independently associated with SAA levels (P = 3.84 × 10−145 and P = 1.05 × 10−29, respectively). SAA levels were positively associated with leukocyte counts and multiple inflammatory marker levels in CAD patients and with body mass index, hemoglobin, high-density lipoprotein cholesterol, and alanine aminotransferase levels in TWB participants. By stepwise linear regression analysis, SAA1 gene variants contributed to 27.53% and 8.07% of the variation of the SAA levels in TWB and CAD populations, respectively, revealing a stronger influence of these two variants in TWB participants compared to CAD patients. Kaplan–Meier survival analysis revealed that SAA levels, but not SAA1 gene variants, were associated with long-term outcomes in patients with CAD. Cox regression analysis also indicated that high circulating SAA levels were an independent predictor of both the primary and secondary endpoints. Conclusion: SAA1 genotypes contributed significantly to SAA levels in the general population and in patients with CAD. Circulating SAA levels but not SAA1 genetic variants could predict long-term outcomes in patients with angiographically confirmed CAD. |
| format | Article |
| id | doaj-art-de6eec823b4d4c4baefc7f04586e3877 |
| institution | Kabale University |
| issn | 1016-3190 2223-8956 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Tzu Chi Medical Journal |
| spelling | doaj-art-de6eec823b4d4c4baefc7f04586e38772025-08-20T03:48:36ZengWolters Kluwer Medknow PublicationsTzu Chi Medical Journal1016-31902223-89562022-01-0134442343310.4103/tcmj.tcmj_219_21Circulating serum amyloid A levels but not SAA1 variants predict long-term outcomes of angiographically confirmed coronary artery diseaseKuan-Hung YehLung-An HsuJyh-Ming Jimmy JuangFu-Tien ChiangMing-Sheng TengI-Shiang TzengSemon WuJeng-Feng LinYu-Lin KoObjectives: Circulating serum amyloid A (SAA) levels are strongly associated with atherosclerotic cardiovascular disease risk and severity. The association between SAA1 genetic variants, SAA levels, inflammatory marker levels, and coronary artery disease (CAD) prognosis has not been fully understood. Materials and Methods: In total, 2199 Taiwan Biobank (TWB) participants were enrolled for a genome-wide association study (GWAS), and the long-term outcomes in 481 patients with CAD were analyzed. The primary endpoint was all-cause mortality, and the secondary endpoint was the combination of all-cause death, myocardial infarction, stroke, and hospitalization for heart failure. Results: Through GWAS, SAA1 rs11024600 and rs7112278 were independently associated with SAA levels (P = 3.84 × 10−145 and P = 1.05 × 10−29, respectively). SAA levels were positively associated with leukocyte counts and multiple inflammatory marker levels in CAD patients and with body mass index, hemoglobin, high-density lipoprotein cholesterol, and alanine aminotransferase levels in TWB participants. By stepwise linear regression analysis, SAA1 gene variants contributed to 27.53% and 8.07% of the variation of the SAA levels in TWB and CAD populations, respectively, revealing a stronger influence of these two variants in TWB participants compared to CAD patients. Kaplan–Meier survival analysis revealed that SAA levels, but not SAA1 gene variants, were associated with long-term outcomes in patients with CAD. Cox regression analysis also indicated that high circulating SAA levels were an independent predictor of both the primary and secondary endpoints. Conclusion: SAA1 genotypes contributed significantly to SAA levels in the general population and in patients with CAD. Circulating SAA levels but not SAA1 genetic variants could predict long-term outcomes in patients with angiographically confirmed CAD.http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=4;spage=423;epage=433;aulast=Yehcoronary artery diseasegenome-wide association studylong-term outcomessaa1 geneserum amyloid a |
| spellingShingle | Kuan-Hung Yeh Lung-An Hsu Jyh-Ming Jimmy Juang Fu-Tien Chiang Ming-Sheng Teng I-Shiang Tzeng Semon Wu Jeng-Feng Lin Yu-Lin Ko Circulating serum amyloid A levels but not SAA1 variants predict long-term outcomes of angiographically confirmed coronary artery disease Tzu Chi Medical Journal coronary artery disease genome-wide association study long-term outcomes saa1 gene serum amyloid a |
| title | Circulating serum amyloid A levels but not SAA1 variants predict long-term outcomes of angiographically confirmed coronary artery disease |
| title_full | Circulating serum amyloid A levels but not SAA1 variants predict long-term outcomes of angiographically confirmed coronary artery disease |
| title_fullStr | Circulating serum amyloid A levels but not SAA1 variants predict long-term outcomes of angiographically confirmed coronary artery disease |
| title_full_unstemmed | Circulating serum amyloid A levels but not SAA1 variants predict long-term outcomes of angiographically confirmed coronary artery disease |
| title_short | Circulating serum amyloid A levels but not SAA1 variants predict long-term outcomes of angiographically confirmed coronary artery disease |
| title_sort | circulating serum amyloid a levels but not saa1 variants predict long term outcomes of angiographically confirmed coronary artery disease |
| topic | coronary artery disease genome-wide association study long-term outcomes saa1 gene serum amyloid a |
| url | http://www.tcmjmed.com/article.asp?issn=1016-3190;year=2022;volume=34;issue=4;spage=423;epage=433;aulast=Yeh |
| work_keys_str_mv | AT kuanhungyeh circulatingserumamyloidalevelsbutnotsaa1variantspredictlongtermoutcomesofangiographicallyconfirmedcoronaryarterydisease AT lunganhsu circulatingserumamyloidalevelsbutnotsaa1variantspredictlongtermoutcomesofangiographicallyconfirmedcoronaryarterydisease AT jyhmingjimmyjuang circulatingserumamyloidalevelsbutnotsaa1variantspredictlongtermoutcomesofangiographicallyconfirmedcoronaryarterydisease AT futienchiang circulatingserumamyloidalevelsbutnotsaa1variantspredictlongtermoutcomesofangiographicallyconfirmedcoronaryarterydisease AT mingshengteng circulatingserumamyloidalevelsbutnotsaa1variantspredictlongtermoutcomesofangiographicallyconfirmedcoronaryarterydisease AT ishiangtzeng circulatingserumamyloidalevelsbutnotsaa1variantspredictlongtermoutcomesofangiographicallyconfirmedcoronaryarterydisease AT semonwu circulatingserumamyloidalevelsbutnotsaa1variantspredictlongtermoutcomesofangiographicallyconfirmedcoronaryarterydisease AT jengfenglin circulatingserumamyloidalevelsbutnotsaa1variantspredictlongtermoutcomesofangiographicallyconfirmedcoronaryarterydisease AT yulinko circulatingserumamyloidalevelsbutnotsaa1variantspredictlongtermoutcomesofangiographicallyconfirmedcoronaryarterydisease |