Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans.
In the neocortex, ~90 Hz ripples couple to ~12 Hz sleep spindles on the ~1 Hz Down-to-Up state transition during non-rapid eye movement sleep. This conjunction of sleep waves is critical for the consolidation of memories into long-term storage. The widespread co-occurrences of ripples ("co-ripp...
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Public Library of Science (PLoS)
2024-11-01
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| Series: | PLoS Biology |
| Online Access: | https://doi.org/10.1371/journal.pbio.3002855 |
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| author | Charles W Dickey Ilya A Verzhbinsky Sophie Kajfez Burke Q Rosen Christopher E Gonzalez Patrick Y Chauvel Sydney S Cash Sandipan Pati Eric Halgren |
| author_facet | Charles W Dickey Ilya A Verzhbinsky Sophie Kajfez Burke Q Rosen Christopher E Gonzalez Patrick Y Chauvel Sydney S Cash Sandipan Pati Eric Halgren |
| author_sort | Charles W Dickey |
| collection | DOAJ |
| description | In the neocortex, ~90 Hz ripples couple to ~12 Hz sleep spindles on the ~1 Hz Down-to-Up state transition during non-rapid eye movement sleep. This conjunction of sleep waves is critical for the consolidation of memories into long-term storage. The widespread co-occurrences of ripples ("co-ripples") may integrate information across the neocortex and hippocampus to facilitate consolidation. While the thalamus synchronizes spindles and Up states in the cortex for memory, it is not known whether it may also organize co-ripples. Using human intracranial recordings during NREM sleep, we investigated whether cortico-cortical co-ripples and hippocampo-cortical co-ripples are either: (1) driven by directly projected thalamic ripples; or (2) coordinated by propagating thalamic spindles or Up states. We found ripples in the anterior and posterior thalamus, with similar characteristics as hippocampal and cortical ripples, including having a center frequency of ~90 Hz and coupling to local spindles on the Down-to-Up state transition. However, thalamic ripples rarely co-occur or phase-lock with cortical or hippocampal ripples. By contrast, spindles and Up states that propagate from the thalamus strongly coordinate co-ripples in the cortex and hippocampus. Thus, thalamo-cortical spindles and Up states, rather than thalamic ripples, may provide input facilitating spatially distributed co-rippling that integrates information for memory consolidation during sleep in humans. |
| format | Article |
| id | doaj-art-de671eeefd3a4835a2cdb5ccfaf652a9 |
| institution | Kabale University |
| issn | 1544-9173 1545-7885 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS Biology |
| spelling | doaj-art-de671eeefd3a4835a2cdb5ccfaf652a92025-01-08T05:30:24ZengPublic Library of Science (PLoS)PLoS Biology1544-91731545-78852024-11-012211e300285510.1371/journal.pbio.3002855Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans.Charles W DickeyIlya A VerzhbinskySophie KajfezBurke Q RosenChristopher E GonzalezPatrick Y ChauvelSydney S CashSandipan PatiEric HalgrenIn the neocortex, ~90 Hz ripples couple to ~12 Hz sleep spindles on the ~1 Hz Down-to-Up state transition during non-rapid eye movement sleep. This conjunction of sleep waves is critical for the consolidation of memories into long-term storage. The widespread co-occurrences of ripples ("co-ripples") may integrate information across the neocortex and hippocampus to facilitate consolidation. While the thalamus synchronizes spindles and Up states in the cortex for memory, it is not known whether it may also organize co-ripples. Using human intracranial recordings during NREM sleep, we investigated whether cortico-cortical co-ripples and hippocampo-cortical co-ripples are either: (1) driven by directly projected thalamic ripples; or (2) coordinated by propagating thalamic spindles or Up states. We found ripples in the anterior and posterior thalamus, with similar characteristics as hippocampal and cortical ripples, including having a center frequency of ~90 Hz and coupling to local spindles on the Down-to-Up state transition. However, thalamic ripples rarely co-occur or phase-lock with cortical or hippocampal ripples. By contrast, spindles and Up states that propagate from the thalamus strongly coordinate co-ripples in the cortex and hippocampus. Thus, thalamo-cortical spindles and Up states, rather than thalamic ripples, may provide input facilitating spatially distributed co-rippling that integrates information for memory consolidation during sleep in humans.https://doi.org/10.1371/journal.pbio.3002855 |
| spellingShingle | Charles W Dickey Ilya A Verzhbinsky Sophie Kajfez Burke Q Rosen Christopher E Gonzalez Patrick Y Chauvel Sydney S Cash Sandipan Pati Eric Halgren Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans. PLoS Biology |
| title | Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans. |
| title_full | Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans. |
| title_fullStr | Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans. |
| title_full_unstemmed | Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans. |
| title_short | Thalamic spindles and Up states coordinate cortical and hippocampal co-ripples in humans. |
| title_sort | thalamic spindles and up states coordinate cortical and hippocampal co ripples in humans |
| url | https://doi.org/10.1371/journal.pbio.3002855 |
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