Prognostic Effect of pan-Immune-Inflammation Value Indices in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention
Background This study aimed to investigate the association of pan-immune-inflammation value (PIV), PIV/HDL-C (high-density lipoprotein cholesterol), PIV*LDL-C (low-density lipoprotein cholesterol) with the prognosis of patients with acute coronary syndrome (ACS) undergoing percutaneous coronary inte...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2025-05-01
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| Series: | Clinical and Applied Thrombosis/Hemostasis |
| Online Access: | https://doi.org/10.1177/10760296251343838 |
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| author | Yan Liu MM Xinchen Wang MM Ge Song MM Chen Wei MM Jingyi Liu MD Yuewen Qi MM Weichao Shan MM Ying Zhang MD Lixian Sun MD |
| author_facet | Yan Liu MM Xinchen Wang MM Ge Song MM Chen Wei MM Jingyi Liu MD Yuewen Qi MM Weichao Shan MM Ying Zhang MD Lixian Sun MD |
| author_sort | Yan Liu MM |
| collection | DOAJ |
| description | Background This study aimed to investigate the association of pan-immune-inflammation value (PIV), PIV/HDL-C (high-density lipoprotein cholesterol), PIV*LDL-C (low-density lipoprotein cholesterol) with the prognosis of patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Methods A total of 1360 patients with ACS undergoing PCI were consecutively enrolled in this study. They were divided into major adverse cardiovascular events (MACEs) (n = 58) and non-MACEs (n = 1302) groups. The PIV, PIV/HDL-C, and PIV*LDL-C values were measured. The endpoints were MACEs, including cardiogenic mortality, recurrence of myocardial infarction, in-stent restenosis, and rehospitalization for severe heart failure. Results The multivariable Cox regression analysis showed that PIV ≥355.79 (hazard ratio [HR]: 2.006, 95% confidence interval [CI]: 1.165-3.455), PIV/HDL-C ≥ 282.86 (HR: 1.987, 95% CI: 1.119-3.527), and PIV*LDL-C ≥ 1431.58 (HR: 2.071, 95% CI: 1.206-3.556) were all independent predictors of MACEs in patients with ACS undergoing PCI (all P < .05). The cumulative survival rates were significantly lower for patients with higher PIV, PIV/HDL-C, and PIV*LDL-C than for patients with lower values of these indices (log-rank tests: all P < .05). Conclusion Higher PIV, PIV/HDL-C, and PIV*LDL-C were independent prognostic factors for patients with ACS undergoing PCI and may be novel biomarkers for predicting MACEs. |
| format | Article |
| id | doaj-art-de64abcd84104e99ba7f64953ae3eba4 |
| institution | Kabale University |
| issn | 1938-2723 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Clinical and Applied Thrombosis/Hemostasis |
| spelling | doaj-art-de64abcd84104e99ba7f64953ae3eba42025-08-20T03:49:45ZengSAGE PublishingClinical and Applied Thrombosis/Hemostasis1938-27232025-05-013110.1177/10760296251343838Prognostic Effect of pan-Immune-Inflammation Value Indices in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary InterventionYan Liu MM0Xinchen Wang MM1Ge Song MM2Chen Wei MM3Jingyi Liu MD4Yuewen Qi MM5Weichao Shan MM6Ying Zhang MD7Lixian Sun MD8 Department of Cardiology, , Chengde, China Department of Cardiology, , Chengde, China Department of Cardiology, , Chengde, China Department of Cardiology, , Chengde, China Hebei Key Laboratory of Panvascular Diseases, Chengde, China Central Laboratory of Chengde Medical University Affiliated Hospital, Chengde, China Hebei Key Laboratory of Panvascular Diseases, Chengde, China Hebei Key Laboratory of Panvascular Diseases, Chengde, China Hebei Key Laboratory of Panvascular Diseases, Chengde, ChinaBackground This study aimed to investigate the association of pan-immune-inflammation value (PIV), PIV/HDL-C (high-density lipoprotein cholesterol), PIV*LDL-C (low-density lipoprotein cholesterol) with the prognosis of patients with acute coronary syndrome (ACS) undergoing percutaneous coronary intervention (PCI). Methods A total of 1360 patients with ACS undergoing PCI were consecutively enrolled in this study. They were divided into major adverse cardiovascular events (MACEs) (n = 58) and non-MACEs (n = 1302) groups. The PIV, PIV/HDL-C, and PIV*LDL-C values were measured. The endpoints were MACEs, including cardiogenic mortality, recurrence of myocardial infarction, in-stent restenosis, and rehospitalization for severe heart failure. Results The multivariable Cox regression analysis showed that PIV ≥355.79 (hazard ratio [HR]: 2.006, 95% confidence interval [CI]: 1.165-3.455), PIV/HDL-C ≥ 282.86 (HR: 1.987, 95% CI: 1.119-3.527), and PIV*LDL-C ≥ 1431.58 (HR: 2.071, 95% CI: 1.206-3.556) were all independent predictors of MACEs in patients with ACS undergoing PCI (all P < .05). The cumulative survival rates were significantly lower for patients with higher PIV, PIV/HDL-C, and PIV*LDL-C than for patients with lower values of these indices (log-rank tests: all P < .05). Conclusion Higher PIV, PIV/HDL-C, and PIV*LDL-C were independent prognostic factors for patients with ACS undergoing PCI and may be novel biomarkers for predicting MACEs.https://doi.org/10.1177/10760296251343838 |
| spellingShingle | Yan Liu MM Xinchen Wang MM Ge Song MM Chen Wei MM Jingyi Liu MD Yuewen Qi MM Weichao Shan MM Ying Zhang MD Lixian Sun MD Prognostic Effect of pan-Immune-Inflammation Value Indices in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Clinical and Applied Thrombosis/Hemostasis |
| title | Prognostic Effect of pan-Immune-Inflammation Value Indices in Patients with Acute Coronary Syndrome Undergoing Percutaneous
Coronary Intervention |
| title_full | Prognostic Effect of pan-Immune-Inflammation Value Indices in Patients with Acute Coronary Syndrome Undergoing Percutaneous
Coronary Intervention |
| title_fullStr | Prognostic Effect of pan-Immune-Inflammation Value Indices in Patients with Acute Coronary Syndrome Undergoing Percutaneous
Coronary Intervention |
| title_full_unstemmed | Prognostic Effect of pan-Immune-Inflammation Value Indices in Patients with Acute Coronary Syndrome Undergoing Percutaneous
Coronary Intervention |
| title_short | Prognostic Effect of pan-Immune-Inflammation Value Indices in Patients with Acute Coronary Syndrome Undergoing Percutaneous
Coronary Intervention |
| title_sort | prognostic effect of pan immune inflammation value indices in patients with acute coronary syndrome undergoing percutaneous coronary intervention |
| url | https://doi.org/10.1177/10760296251343838 |
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