Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model
Abstract Research indicated that berberine (BBR) plays a protective role in modulating Alzheimer’s disease (AD). This study aimed to explore the target genes of BBR associated with AD therapy using a network pharmacology study. Through network pharmacology analysis, two main potential target genes,...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-02-01
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| Series: | npj Science of Food |
| Online Access: | https://doi.org/10.1038/s41538-025-00378-y |
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| author | Yaoyi Zhang Shuai Lv Pinyuan Huang Lingmin Xiao Nan Lin En Huang |
| author_facet | Yaoyi Zhang Shuai Lv Pinyuan Huang Lingmin Xiao Nan Lin En Huang |
| author_sort | Yaoyi Zhang |
| collection | DOAJ |
| description | Abstract Research indicated that berberine (BBR) plays a protective role in modulating Alzheimer’s disease (AD). This study aimed to explore the target genes of BBR associated with AD therapy using a network pharmacology study. Through network pharmacology analysis, two main potential target genes, β-amyloid precursor protein (APP) and peroxisome proliferator-activated receptor gamma (PPARG), of BBR for AD therapy were screened out. Further experiments demonstrated that BV2 and C8-D1A treated with BBR were decreased in the mRNA and protein expression of APP and presenilin 1 while PPARG was increased with a reduction in the NF-κB pathway. A similar result was shown in vivo. Through a network pharmacology study, this study supported that BBR played a protective role in the AD mice model via blocking APP processing and amyloid plaque formation. It also promotes PPARG expression to blockage of NF-κB pathway-mediated inflammatory response and neuroinflammation. |
| format | Article |
| id | doaj-art-de616859c6ac4dd3a02c77fb6099c6d2 |
| institution | Kabale University |
| issn | 2396-8370 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Science of Food |
| spelling | doaj-art-de616859c6ac4dd3a02c77fb6099c6d22025-02-09T12:56:11ZengNature Portfolionpj Science of Food2396-83702025-02-019111610.1038/s41538-025-00378-yNetwork pharmacology study on the mechanism of berberine in Alzheimer’s disease modelYaoyi Zhang0Shuai Lv1Pinyuan Huang2Lingmin Xiao3Nan Lin4En Huang5Key Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province, School of Basic Medical Sciences, Fujian Medical UniversityDepartment of Pediatrics, The First Affiliated Hospital of Dalian Medical UniversityKey Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province, School of Basic Medical Sciences, Fujian Medical UniversityKey Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province, School of Basic Medical Sciences, Fujian Medical UniversityFujian Key Laboratory of Vascular Aging, Department of Geriatrics, Fujian Institute of Geriatrics, Fujian Clinical Research Center for Senile Vascular Aging and Brain Aging, Fujian Medical University Union HospitalKey Laboratory of Brain Aging and Neurodegenerative Diseases of Fujian Province, School of Basic Medical Sciences, Fujian Medical UniversityAbstract Research indicated that berberine (BBR) plays a protective role in modulating Alzheimer’s disease (AD). This study aimed to explore the target genes of BBR associated with AD therapy using a network pharmacology study. Through network pharmacology analysis, two main potential target genes, β-amyloid precursor protein (APP) and peroxisome proliferator-activated receptor gamma (PPARG), of BBR for AD therapy were screened out. Further experiments demonstrated that BV2 and C8-D1A treated with BBR were decreased in the mRNA and protein expression of APP and presenilin 1 while PPARG was increased with a reduction in the NF-κB pathway. A similar result was shown in vivo. Through a network pharmacology study, this study supported that BBR played a protective role in the AD mice model via blocking APP processing and amyloid plaque formation. It also promotes PPARG expression to blockage of NF-κB pathway-mediated inflammatory response and neuroinflammation.https://doi.org/10.1038/s41538-025-00378-y |
| spellingShingle | Yaoyi Zhang Shuai Lv Pinyuan Huang Lingmin Xiao Nan Lin En Huang Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model npj Science of Food |
| title | Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model |
| title_full | Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model |
| title_fullStr | Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model |
| title_full_unstemmed | Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model |
| title_short | Network pharmacology study on the mechanism of berberine in Alzheimer’s disease model |
| title_sort | network pharmacology study on the mechanism of berberine in alzheimer s disease model |
| url | https://doi.org/10.1038/s41538-025-00378-y |
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