Efficient Synthesis of Novel 10R-Pyrido[4,3-a]Phenazines, Including the Series Progenitor
A series of previously poorly studied heterocyclic compounds, 10R-pyrido[4,3-a]phenazines, including the previously unknown parent compound, has been synthesized. The proposed synthetic approach is remarkable for its simplicity, due to the ease of the synthesis of the starting materials from readily...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-06-01
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| Series: | Organics |
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| Online Access: | https://www.mdpi.com/2673-401X/6/2/24 |
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| author | Artem P. Ermolenko Diana Y. Pobedinskaya Elena K. Avakyan Anastasia A. Borovleva Alexander N. Larin Ivan V. Borovlev Oleg P. Demidov |
| author_facet | Artem P. Ermolenko Diana Y. Pobedinskaya Elena K. Avakyan Anastasia A. Borovleva Alexander N. Larin Ivan V. Borovlev Oleg P. Demidov |
| author_sort | Artem P. Ermolenko |
| collection | DOAJ |
| description | A series of previously poorly studied heterocyclic compounds, 10R-pyrido[4,3-a]phenazines, including the previously unknown parent compound, has been synthesized. The proposed synthetic approach is remarkable for its simplicity, due to the ease of the synthesis of the starting materials from readily available precursors, and is characterized by high yields of the target products, achievable under both acidic and basic catalysis. The paper discusses the synthesis conditions, optimization procedures, and X-ray crystallographic data. |
| format | Article |
| id | doaj-art-de60b595ca0b4afe997b71fbe5385118 |
| institution | DOAJ |
| issn | 2673-401X |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Organics |
| spelling | doaj-art-de60b595ca0b4afe997b71fbe53851182025-08-20T03:16:21ZengMDPI AGOrganics2673-401X2025-06-01622410.3390/org6020024Efficient Synthesis of Novel 10R-Pyrido[4,3-a]Phenazines, Including the Series ProgenitorArtem P. Ermolenko0Diana Y. Pobedinskaya1Elena K. Avakyan2Anastasia A. Borovleva3Alexander N. Larin4Ivan V. Borovlev5Oleg P. Demidov6Department of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, RussiaDepartment of Chemistry, North Caucasus Federal University, 1a Pushkin St., Stavropol 355017, RussiaA series of previously poorly studied heterocyclic compounds, 10R-pyrido[4,3-a]phenazines, including the previously unknown parent compound, has been synthesized. The proposed synthetic approach is remarkable for its simplicity, due to the ease of the synthesis of the starting materials from readily available precursors, and is characterized by high yields of the target products, achievable under both acidic and basic catalysis. The paper discusses the synthesis conditions, optimization procedures, and X-ray crystallographic data.https://www.mdpi.com/2673-401X/6/2/24phenazinespyrido[4,3-a]phenazineintramolecular cyclizationcrystal structure5-nitrosoisoquinoline |
| spellingShingle | Artem P. Ermolenko Diana Y. Pobedinskaya Elena K. Avakyan Anastasia A. Borovleva Alexander N. Larin Ivan V. Borovlev Oleg P. Demidov Efficient Synthesis of Novel 10R-Pyrido[4,3-a]Phenazines, Including the Series Progenitor Organics phenazines pyrido[4,3-a]phenazine intramolecular cyclization crystal structure 5-nitrosoisoquinoline |
| title | Efficient Synthesis of Novel 10R-Pyrido[4,3-a]Phenazines, Including the Series Progenitor |
| title_full | Efficient Synthesis of Novel 10R-Pyrido[4,3-a]Phenazines, Including the Series Progenitor |
| title_fullStr | Efficient Synthesis of Novel 10R-Pyrido[4,3-a]Phenazines, Including the Series Progenitor |
| title_full_unstemmed | Efficient Synthesis of Novel 10R-Pyrido[4,3-a]Phenazines, Including the Series Progenitor |
| title_short | Efficient Synthesis of Novel 10R-Pyrido[4,3-a]Phenazines, Including the Series Progenitor |
| title_sort | efficient synthesis of novel 10r pyrido 4 3 a phenazines including the series progenitor |
| topic | phenazines pyrido[4,3-a]phenazine intramolecular cyclization crystal structure 5-nitrosoisoquinoline |
| url | https://www.mdpi.com/2673-401X/6/2/24 |
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