FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling

FGF21 acts in the brain to drive macronutrient-specific changes in behavioral motivation and brain reward signaling

Objective: Dietary protein restriction induces adaptive changes in food preference, increasing protein consumption over carbohydrates or fat. We investigated whether motivation and reward signaling underpin these preferences. Methods and Results: In an operant task, protein-restricted male mice resp...

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Main Authors: Md Shahjalal H. Khan, Sora Q. Kim, Robert C. Ross, Florina Corpodean, Redin A. Spann, Diana A. Albarado, Sun O. Fernandez-Kim, Blaise Clarke, Hans-Rudolf Berthoud, Heike Münzberg, David H. McDougal, Yanlin He, Sangho Yu, Vance L. Albaugh, Paul L. Soto, Christopher D. Morrison
Format: Article
Language:English
Published: Elsevier 2025-01-01
Series:Molecular Metabolism
Subjects:
FGF21
Dietary protein
Motivation
Food preference
Online Access:http://www.sciencedirect.com/science/article/pii/S2212877824001996
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