Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen, China
[Objective] To conduct a retrospective statistical comparison of alanine aminotransferase (ALT) test values in blood donors prior to blood collection, aiming to analyze the objective characteristics of the population with elevated ALT levels (ALT>50 U/L) and provide reference data for adjusting t...
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Institute of Blood Transfusion of Chinese Academy of Medical Sciences
2025-04-01
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| Series: | Zhongguo shuxue zazhi |
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| Online Access: | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.005&lang=en |
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| author | ZHENG Xin XUE Yuanye WANG Haobiao WU Litiao LI Ran DANG Yingnan CHEN Tingting XU Xiaoxuan ZENG Xuezhen ZENG Jinfeng |
| author_facet | ZHENG Xin XUE Yuanye WANG Haobiao WU Litiao LI Ran DANG Yingnan CHEN Tingting XU Xiaoxuan ZENG Xuezhen ZENG Jinfeng |
| author_sort | ZHENG Xin |
| collection | DOAJ |
| description | [Objective] To conduct a retrospective statistical comparison of alanine aminotransferase (ALT) test values in blood donors prior to blood collection, aiming to analyze the objective characteristics of the population with elevated ALT levels (ALT>50 U/L) and provide reference data for adjusting the screening eligibility threshold for ALT. [Methods] The preliminary ALT screening data of 30 341 blood donor samples collected prior to blood donation from three smart blood donation sites at the Shenzhen Blood Center between 2022 and 2023 were extracted and compared with data from a health examination department of a tertiary hospital in Shenzhen (representing the general population, n=24 906). Both datasets were categorized and statistically described. A retrospective analysis was conducted to examine the associations between ALT test results and factors such as donors' gender, age, ethnicity, donation site, donation season, and frequency of blood donation. [Results] The ALT levels in both blood donors and the general population were non-normally distributed. The 95th percentile of ALT values was calculated as 61.4 U/L (male: 67.8 U/L, female: 39.3 U/L) for blood donors and 58.1 U/L (male: 63.7 U/L, female: 51.2 U/L) for the general population. The non-compliance rates (ALT>50 U/L) were 7.65% (2 321/30 341) in blood donors and 7.08% (1 763/24 906) in the general population. There were significant differences (P<0.05) in the ALT failure rate among blood donors based on gender, age, and donation site, but no significant differences (P>0.05) during the blood donation season. There was no statistically significant difference (P>0.05) in the positive rates of four serological markers (HBsAg, anti HCV, HIV Ag/Ab, anti TP) for blood screening pathogens between ALT unqualified and qualified individuals (2.05% vs 1.5%). If the ALT qualification threshold was raised from 50 U/L to 90 U/L, the non qualification rates of male and female blood donors would decrease from 9.82% (2 074/21 125) to 2.23% (471/21 125) and from 2.70% (249/9 216) to 0.75% (69/9 216), respectively. Among the 154 blood donors who donated blood more than 3 times, 88.31% of the 248 ALT test results were in the range of 50-90 U/L. Among them, 9 cases had ALT>130 U/L, and ALT was converted to qualified in subsequent blood donations. [Conclusion] There are differences in the ALT failure rate among blood donors of different genders and ages, and different blood donation sites and operators can also affect the ALT detection values of blood donors. The vast majority of blood donors with ALT failure are caused by transient and non pathological factors. With the widespread use of blood virus nucleic acid testing, appropriately increasing the ALT qualification threshold for blood donors can expand the qualified population and alleviate the shortage of blood sources, and the risk of blood safety will not increase. |
| format | Article |
| id | doaj-art-de57b67f7fff49afa92daeb0b4e48f39 |
| institution | OA Journals |
| issn | 1004-549X |
| language | zho |
| publishDate | 2025-04-01 |
| publisher | Institute of Blood Transfusion of Chinese Academy of Medical Sciences |
| record_format | Article |
| series | Zhongguo shuxue zazhi |
| spelling | doaj-art-de57b67f7fff49afa92daeb0b4e48f392025-08-20T02:28:19ZzhoInstitute of Blood Transfusion of Chinese Academy of Medical SciencesZhongguo shuxue zazhi1004-549X2025-04-0138448849410.13303/j.cjbt.issn.1004-549x.2025.04.0051004-549X(2025)4-0488-07Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen, ChinaZHENG Xin0XUE Yuanye1WANG Haobiao2WU Litiao3LI Ran4DANG Yingnan5CHEN Tingting6XU Xiaoxuan7ZENG Xuezhen8ZENG Jinfeng9Shenzhen Blood Center, Shenzhen 518172, ChinaShenzhen Blood Center, Shenzhen 518172, ChinaShenzhen Blood Center, Shenzhen 518172, ChinaShenzhen Blood Center, Shenzhen 518172, ChinaShenzhen Blood Center, Shenzhen 518172, ChinaQinghai Provincial Blood Center, Xining 810000, ChinaShenzhen Blood Center, Shenzhen 518172, ChinaShenzhen Blood Center, Shenzhen 518172, ChinaShenzhen Blood Center, Shenzhen 518172, ChinaShenzhen Blood Center, Shenzhen 518172, China[Objective] To conduct a retrospective statistical comparison of alanine aminotransferase (ALT) test values in blood donors prior to blood collection, aiming to analyze the objective characteristics of the population with elevated ALT levels (ALT>50 U/L) and provide reference data for adjusting the screening eligibility threshold for ALT. [Methods] The preliminary ALT screening data of 30 341 blood donor samples collected prior to blood donation from three smart blood donation sites at the Shenzhen Blood Center between 2022 and 2023 were extracted and compared with data from a health examination department of a tertiary hospital in Shenzhen (representing the general population, n=24 906). Both datasets were categorized and statistically described. A retrospective analysis was conducted to examine the associations between ALT test results and factors such as donors' gender, age, ethnicity, donation site, donation season, and frequency of blood donation. [Results] The ALT levels in both blood donors and the general population were non-normally distributed. The 95th percentile of ALT values was calculated as 61.4 U/L (male: 67.8 U/L, female: 39.3 U/L) for blood donors and 58.1 U/L (male: 63.7 U/L, female: 51.2 U/L) for the general population. The non-compliance rates (ALT>50 U/L) were 7.65% (2 321/30 341) in blood donors and 7.08% (1 763/24 906) in the general population. There were significant differences (P<0.05) in the ALT failure rate among blood donors based on gender, age, and donation site, but no significant differences (P>0.05) during the blood donation season. There was no statistically significant difference (P>0.05) in the positive rates of four serological markers (HBsAg, anti HCV, HIV Ag/Ab, anti TP) for blood screening pathogens between ALT unqualified and qualified individuals (2.05% vs 1.5%). If the ALT qualification threshold was raised from 50 U/L to 90 U/L, the non qualification rates of male and female blood donors would decrease from 9.82% (2 074/21 125) to 2.23% (471/21 125) and from 2.70% (249/9 216) to 0.75% (69/9 216), respectively. Among the 154 blood donors who donated blood more than 3 times, 88.31% of the 248 ALT test results were in the range of 50-90 U/L. Among them, 9 cases had ALT>130 U/L, and ALT was converted to qualified in subsequent blood donations. [Conclusion] There are differences in the ALT failure rate among blood donors of different genders and ages, and different blood donation sites and operators can also affect the ALT detection values of blood donors. The vast majority of blood donors with ALT failure are caused by transient and non pathological factors. With the widespread use of blood virus nucleic acid testing, appropriately increasing the ALT qualification threshold for blood donors can expand the qualified population and alleviate the shortage of blood sources, and the risk of blood safety will not increase.https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.005&lang=envoluntary blood donorsalanine aminotransferase (alt)blood screeningretrospective statistical analysis |
| spellingShingle | ZHENG Xin XUE Yuanye WANG Haobiao WU Litiao LI Ran DANG Yingnan CHEN Tingting XU Xiaoxuan ZENG Xuezhen ZENG Jinfeng Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen, China Zhongguo shuxue zazhi voluntary blood donors alanine aminotransferase (alt) blood screening retrospective statistical analysis |
| title | Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen, China |
| title_full | Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen, China |
| title_fullStr | Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen, China |
| title_full_unstemmed | Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen, China |
| title_short | Alanine transferase test results and exploration of threshold adjustment strategies for blood donors in Shenzhen, China |
| title_sort | alanine transferase test results and exploration of threshold adjustment strategies for blood donors in shenzhen china |
| topic | voluntary blood donors alanine aminotransferase (alt) blood screening retrospective statistical analysis |
| url | https://www.cjbt.cn/thesisDetails#10.13303/j.cjbt.issn.1004-549x.2025.04.005&lang=en |
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