Compensatory synaptotagmin-11 expression conceals parkinson’s disease-like phenotypes in parkin knockout mice

Compensatory synaptotagmin-11 expression conceals parkinson’s disease-like phenotypes in parkin knockout mice

Abstract Animal models are crucial for elucidating the pathological mechanisms underlying Parkinson’s disease (PD). Unfortunately, most of transgenic mouse models fail to manifest pathological changes observed in PD patients, pending the advancement of PD research. However, the mechanism underlying...

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Bibliographic Details
Main Authors: Nan Dong, Zhenli Xie, Anqi Wei, Yuxin Yang, Yongning Deng, Xu Cheng, Bianbian Wang, Yang Chen, Yuhao Gu, Jingyu Yao, Yuhao Qin, Chaowen Zheng, Xi Zhang, Yuqing Zhang, Xinjiang Kang, Guoqing Chen, Qiumin Qu, Changhe Wang, Huadong Xu
Format: Article
Language:English
Published: BMC 2025-02-01
Series:Cell Communication and Signaling
Subjects:
Parkinson’s disease
Compensatory effect
Parkin
Synaptotagmin-11
Dopamine release
Online Access:https://doi.org/10.1186/s12964-025-02037-x
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