Highly scalable prefusion-stabilized RSV F vaccine with enhanced immunogenicity and robust protection

Highly scalable prefusion-stabilized RSV F vaccine with enhanced immunogenicity and robust protection

Abstract Stabilizing the RSV F protein in its prefusion conformation is crucial for effective vaccine development but has remained a significant challenge. Traditional stabilization methods, such as disulfide bonds and cavity-filling mutations, have been labor-intensive and have often resulted in su...

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Main Authors: Qingrui Huang, Qingyun Lang, Yao Li, Fengjie Wang, Xiaonan Han, Ling Luo, Xiaomin Duan, Xuerong Cao, Yue Wang, Yu Bai, Yaxin Song, Yanpeng Xu, Lianlian Bian, Chenyan Gao, Linqing Zhao, Jinghua Yan
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-63084-z
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