Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats
Abstract Purpose This study aimed to assess the effectiveness of different pulse widths in suppressing bladder overactivity using tibial nerve stimulation (TNS) in cats. Methods Hook electrodes were implanted on the left tibial nerve. Cystometry was conducted by infusing either acetic acid (AA) or n...
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BMC
2025-03-01
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| Series: | European Journal of Medical Research |
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| Online Access: | https://doi.org/10.1186/s40001-025-02453-2 |
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| author | Dongsheng Shang Haoyu Sun Han Deng Gongyue Liu Limin Liao Xing Li |
| author_facet | Dongsheng Shang Haoyu Sun Han Deng Gongyue Liu Limin Liao Xing Li |
| author_sort | Dongsheng Shang |
| collection | DOAJ |
| description | Abstract Purpose This study aimed to assess the effectiveness of different pulse widths in suppressing bladder overactivity using tibial nerve stimulation (TNS) in cats. Methods Hook electrodes were implanted on the left tibial nerve. Cystometry was conducted by infusing either acetic acid (AA) or normal saline (NS). TNS was applied at intensities of 2–4 times the threshold (T) with pulse widths ranging from 60 to 624 µsec. Cystometrograms were used to evaluate the impact of different pulse widths on the micturition reflex. Results Bladder capacity (BC) was significantly reduced to 49.71% ± 6.76% of the NS control level (8.58 ± 1.70 mL) due to AA-induced bladder overactivity (P < 0.001). During AA infusion, TNS at pulse widths of 60, 210, 420, and 624 µsec significantly increased BC to 70.65% ± 9.06%, 73.22% ± 6.28%, 73.79% ± 8.56%, and 76.25% ± 7.95% of the NS control level, respectively (P < 0.001). No significant differences were observed among the four pulse widths (P > 0.05). The threshold intensity (T) was higher at 60 µsec than at 624 µsec (P < 0.01), while T at 210 µsec, 420 µsec, and 624 µsec showed no significant differences (P > 0.05). Conclusions All four pulse widths demonstrated inhibitory effects on bladder overactivity. However, no significant differences were observed among the four pulse widths. |
| format | Article |
| id | doaj-art-de493dbd70d44032a2a3e51ef0c8d61e |
| institution | Kabale University |
| issn | 2047-783X |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
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| series | European Journal of Medical Research |
| spelling | doaj-art-de493dbd70d44032a2a3e51ef0c8d61e2025-08-20T03:41:41ZengBMCEuropean Journal of Medical Research2047-783X2025-03-013011810.1186/s40001-025-02453-2Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in catsDongsheng Shang0Haoyu Sun1Han Deng2Gongyue Liu3Limin Liao4Xing Li5Department of Rehabilitation, The Second Affiliated Hospital and Yuying Children’S Hospital of Wenzhou Medical UniversityDepartment of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research CenterDepartment of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research CenterDepartment of Urology, Rehabilitation School of Capital Medical University, China Rehabilitation Research CenterDepartment of Rehabilitation, The Second Affiliated Hospital and Yuying Children’S Hospital of Wenzhou Medical UniversityDepartment of Rehabilitation, The Second Affiliated Hospital and Yuying Children’S Hospital of Wenzhou Medical UniversityAbstract Purpose This study aimed to assess the effectiveness of different pulse widths in suppressing bladder overactivity using tibial nerve stimulation (TNS) in cats. Methods Hook electrodes were implanted on the left tibial nerve. Cystometry was conducted by infusing either acetic acid (AA) or normal saline (NS). TNS was applied at intensities of 2–4 times the threshold (T) with pulse widths ranging from 60 to 624 µsec. Cystometrograms were used to evaluate the impact of different pulse widths on the micturition reflex. Results Bladder capacity (BC) was significantly reduced to 49.71% ± 6.76% of the NS control level (8.58 ± 1.70 mL) due to AA-induced bladder overactivity (P < 0.001). During AA infusion, TNS at pulse widths of 60, 210, 420, and 624 µsec significantly increased BC to 70.65% ± 9.06%, 73.22% ± 6.28%, 73.79% ± 8.56%, and 76.25% ± 7.95% of the NS control level, respectively (P < 0.001). No significant differences were observed among the four pulse widths (P > 0.05). The threshold intensity (T) was higher at 60 µsec than at 624 µsec (P < 0.01), while T at 210 µsec, 420 µsec, and 624 µsec showed no significant differences (P > 0.05). Conclusions All four pulse widths demonstrated inhibitory effects on bladder overactivity. However, no significant differences were observed among the four pulse widths.https://doi.org/10.1186/s40001-025-02453-2Pulse widthsTibial nerve stimulationOveractive bladderCystometryCats |
| spellingShingle | Dongsheng Shang Haoyu Sun Han Deng Gongyue Liu Limin Liao Xing Li Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats European Journal of Medical Research Pulse widths Tibial nerve stimulation Overactive bladder Cystometry Cats |
| title | Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats |
| title_full | Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats |
| title_fullStr | Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats |
| title_full_unstemmed | Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats |
| title_short | Effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats |
| title_sort | effects of different pulse widths on acute tibial nerve stimulation for overactive bladder in cats |
| topic | Pulse widths Tibial nerve stimulation Overactive bladder Cystometry Cats |
| url | https://doi.org/10.1186/s40001-025-02453-2 |
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