Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice
Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2014-01-01
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| Series: | International Journal of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2014/130981 |
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| author | Hang Yang Haili Qi Jingli Ren Jing Cui Zhenfeng Li Helge L. Waldum Guanglin Cui |
| author_facet | Hang Yang Haili Qi Jingli Ren Jing Cui Zhenfeng Li Helge L. Waldum Guanglin Cui |
| author_sort | Hang Yang |
| collection | DOAJ |
| description | Nuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14, 16, 18, and 22 weeks for the examination of tumor burden, inflammation degree, and protein level of NF-κB and IL-6 in bowel tissues. The results showed that tumor burden and inflammation severity in the bowels were gradually increased over the observed time-points. The expressions of IL-6 and NF-κB proteins were gradually increased after induction of dysplastic lesions over times. These data provide new information on the dynamic temporal changes of NF-κB/IL-6 pathway in relation to CAC development that may be relevant in the design of future investigations of therapeutic interventions to effectively target CAC processes. |
| format | Article |
| id | doaj-art-de4679cd8c764d7e9c46e95fca1ed154 |
| institution | Kabale University |
| issn | 2090-8040 2042-0099 |
| language | English |
| publishDate | 2014-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Inflammation |
| spelling | doaj-art-de4679cd8c764d7e9c46e95fca1ed1542025-08-20T03:26:30ZengWileyInternational Journal of Inflammation2090-80402042-00992014-01-01201410.1155/2014/130981130981Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis MiceHang Yang0Haili Qi1Jingli Ren2Jing Cui3Zhenfeng Li4Helge L. Waldum5Guanglin Cui6Department of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, ChinaDepartment of Pathology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, ChinaDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, ChinaInstitute of Clinical Medicine, Norwegian University of Science and Technology, 7489 Trondheim, NorwayDepartment of Gastroenterology, The Second Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 455000, ChinaNuclear factor-kappaB (NF-κB)/interleukin (IL-6) pathway links chronic inflammation to colitis associated cancer (CAC). In this study, we examined the dynamic temporal changes of the NF-κB/IL-6 pathway during the procession of experimental CAC mouse model. Mice were sacrificed after induction for 14, 16, 18, and 22 weeks for the examination of tumor burden, inflammation degree, and protein level of NF-κB and IL-6 in bowel tissues. The results showed that tumor burden and inflammation severity in the bowels were gradually increased over the observed time-points. The expressions of IL-6 and NF-κB proteins were gradually increased after induction of dysplastic lesions over times. These data provide new information on the dynamic temporal changes of NF-κB/IL-6 pathway in relation to CAC development that may be relevant in the design of future investigations of therapeutic interventions to effectively target CAC processes.http://dx.doi.org/10.1155/2014/130981 |
| spellingShingle | Hang Yang Haili Qi Jingli Ren Jing Cui Zhenfeng Li Helge L. Waldum Guanglin Cui Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice International Journal of Inflammation |
| title | Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
| title_full | Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
| title_fullStr | Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
| title_full_unstemmed | Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
| title_short | Involvement of NF-κB/IL-6 Pathway in the Processing of Colorectal Carcinogenesis in Colitis Mice |
| title_sort | involvement of nf κb il 6 pathway in the processing of colorectal carcinogenesis in colitis mice |
| url | http://dx.doi.org/10.1155/2014/130981 |
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