CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ
IntroductionHead and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3ζ) is central to various signalling pathways and is pivotal in tumour progre...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2024.1498139/full |
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| author | Juan Tang Juan Tang Donglin Yu Donglin Yu Jiaojiao Song Junfei Li Junfei Li Yijuan Zhang Xiangrui Ma Xiangrui Ma Wenlong Wang Wenlong Wang |
| author_facet | Juan Tang Juan Tang Donglin Yu Donglin Yu Jiaojiao Song Junfei Li Junfei Li Yijuan Zhang Xiangrui Ma Xiangrui Ma Wenlong Wang Wenlong Wang |
| author_sort | Juan Tang |
| collection | DOAJ |
| description | IntroductionHead and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3ζ) is central to various signalling pathways and is pivotal in tumour progression.MethodsCancerous and corresponding non-cancerous tissue samples were collected from five patients diagnosed with HNSCC. circRNA and mRNA expression profiles were analyzed using high-throughput sequencing techniques. Potential circRNA-microRNA (miRNA)-mRNA interactions were predicted using bioinformatics tools.ResultsThe study found that CircRNA_036186 regulates the expression of 14-3-3ζ in HNSCC through miR-193b-5p.DiscussionThese findings suggest that CircRNA_036186 has the potential to be a biomarker and therapeutic target for HNSCC and provide some theoretical basis for further research on the role of circRNA in HNSCC. |
| format | Article |
| id | doaj-art-de458534a5f647fab11b5659bf3e06cb |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-de458534a5f647fab11b5659bf3e06cb2025-08-20T02:38:30ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-12-011410.3389/fonc.2024.14981391498139CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζJuan Tang0Juan Tang1Donglin Yu2Donglin Yu3Jiaojiao Song4Junfei Li5Junfei Li6Yijuan Zhang7Xiangrui Ma8Xiangrui Ma9Wenlong Wang10Wenlong Wang11Department of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, ChinaSchool of Stomatology, Binzhou Medical University, Yantai, ChinaDepartment of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, ChinaSchool of Stomatology, Binzhou Medical University, Yantai, ChinaPlantation Center, Weihai Stomatological Hospital, Weihai, ChinaDepartment of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, ChinaSchool of Stomatology, Binzhou Medical University, Yantai, ChinaDepartment of Anesthesiology, Binzhou Medical University Hospital, Binzhou, ChinaDepartment of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, ChinaSchool of Stomatology, Binzhou Medical University, Yantai, ChinaDepartment of Oral and Maxillofacial Surgery, Binzhou Medical University Hospital, Binzhou, ChinaSchool of Stomatology, Binzhou Medical University, Yantai, ChinaIntroductionHead and neck squamous cell carcinoma (HNSCC) is a prevalent and lethal malignancy, accounting for 95% of head and neck cancers. Tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activating protein ZETA (14-3-3ζ) is central to various signalling pathways and is pivotal in tumour progression.MethodsCancerous and corresponding non-cancerous tissue samples were collected from five patients diagnosed with HNSCC. circRNA and mRNA expression profiles were analyzed using high-throughput sequencing techniques. Potential circRNA-microRNA (miRNA)-mRNA interactions were predicted using bioinformatics tools.ResultsThe study found that CircRNA_036186 regulates the expression of 14-3-3ζ in HNSCC through miR-193b-5p.DiscussionThese findings suggest that CircRNA_036186 has the potential to be a biomarker and therapeutic target for HNSCC and provide some theoretical basis for further research on the role of circRNA in HNSCC.https://www.frontiersin.org/articles/10.3389/fonc.2024.1498139/fullhead and neck squamous cell carcinomabioinformatics analysishigh throughput sequencing technologyCircRNAMiRNA14-3-3ζ |
| spellingShingle | Juan Tang Juan Tang Donglin Yu Donglin Yu Jiaojiao Song Junfei Li Junfei Li Yijuan Zhang Xiangrui Ma Xiangrui Ma Wenlong Wang Wenlong Wang CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ Frontiers in Oncology head and neck squamous cell carcinoma bioinformatics analysis high throughput sequencing technology CircRNA MiRNA 14-3-3ζ |
| title | CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ |
| title_full | CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ |
| title_fullStr | CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ |
| title_full_unstemmed | CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ |
| title_short | CircRNA_036186 mediates HNSCC progression by regulating 14-3-3ζ |
| title_sort | circrna 036186 mediates hnscc progression by regulating 14 3 3ζ |
| topic | head and neck squamous cell carcinoma bioinformatics analysis high throughput sequencing technology CircRNA MiRNA 14-3-3ζ |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2024.1498139/full |
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