Curcumin delivery nanoparticles based on Maillard reaction of Haematococcus pluvialis protein/galactose for alleviating acute alcoholic liver damage
The aim of this study is to investigate the feasibility of Maillard reaction products of Haematococcus pluvialis protein and galactose (HPP-GAL) for improving the bioactivities of curcumin (CUR) for alleviating alcoholic liver damage. CUR was embedded into HPP-GAL nanoparticles by the self-assembly...
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| Format: | Article |
| Language: | English |
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Tsinghua University Press
2024-09-01
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| Series: | Food Science and Human Wellness |
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| Online Access: | https://www.sciopen.com/article/10.26599/FSHW.2022.9250211 |
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| author | Xinyi Liu Yukun Song Shasha Cheng Mingqian Tan |
| author_facet | Xinyi Liu Yukun Song Shasha Cheng Mingqian Tan |
| author_sort | Xinyi Liu |
| collection | DOAJ |
| description | The aim of this study is to investigate the feasibility of Maillard reaction products of Haematococcus pluvialis protein and galactose (HPP-GAL) for improving the bioactivities of curcumin (CUR) for alleviating alcoholic liver damage. CUR was embedded into HPP-GAL nanoparticles by the self-assembly of hydrogen bonding and hydrophobic interaction with the particle size around 200 nm. HPP-GAL enhanced the encapsulation efficiency and loading amount of CUR with the value of (89.21 ± 0.33)% and (0.500 ± 0.004)%, respectively. The stabilities of CUR under strong acid, salt ion stability and ultraviolet irradiation conditions were improved by the encapsulation. HPP-GAL-CUR nanoparticles exhibited excellent concentration-dependent in vitro antioxidant activities including DPPH and ABTS scavenging rates, and better protective effect on CUR against gastric acid environment as well as longer release of CUR in simulated intestinal fluid. In addition, the HPPGAL-CUR delivery system possessed liver targeting property due to the existence of GAL, which could effectively alleviate the alcohol-induced liver damage and the inflammation indexes by inhibiting the oxidative stress. Therefore, HPP-GAL-CUR nanoparticles might be a potential candidate system for the prevention of alcoholic liver damage in the future. |
| format | Article |
| id | doaj-art-de450fa75713466d80d5ff7dfdc78762 |
| institution | Kabale University |
| issn | 2097-0765 2213-4530 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Tsinghua University Press |
| record_format | Article |
| series | Food Science and Human Wellness |
| spelling | doaj-art-de450fa75713466d80d5ff7dfdc787622025-01-10T06:56:56ZengTsinghua University PressFood Science and Human Wellness2097-07652213-45302024-09-011352629264110.26599/FSHW.2022.9250211Curcumin delivery nanoparticles based on Maillard reaction of Haematococcus pluvialis protein/galactose for alleviating acute alcoholic liver damageXinyi Liu0Yukun Song1Shasha Cheng2Mingqian Tan3School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaSchool of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, ChinaThe aim of this study is to investigate the feasibility of Maillard reaction products of Haematococcus pluvialis protein and galactose (HPP-GAL) for improving the bioactivities of curcumin (CUR) for alleviating alcoholic liver damage. CUR was embedded into HPP-GAL nanoparticles by the self-assembly of hydrogen bonding and hydrophobic interaction with the particle size around 200 nm. HPP-GAL enhanced the encapsulation efficiency and loading amount of CUR with the value of (89.21 ± 0.33)% and (0.500 ± 0.004)%, respectively. The stabilities of CUR under strong acid, salt ion stability and ultraviolet irradiation conditions were improved by the encapsulation. HPP-GAL-CUR nanoparticles exhibited excellent concentration-dependent in vitro antioxidant activities including DPPH and ABTS scavenging rates, and better protective effect on CUR against gastric acid environment as well as longer release of CUR in simulated intestinal fluid. In addition, the HPPGAL-CUR delivery system possessed liver targeting property due to the existence of GAL, which could effectively alleviate the alcohol-induced liver damage and the inflammation indexes by inhibiting the oxidative stress. Therefore, HPP-GAL-CUR nanoparticles might be a potential candidate system for the prevention of alcoholic liver damage in the future.https://www.sciopen.com/article/10.26599/FSHW.2022.9250211haematococcus pluvialis proteingalactosecurcumin nanocarriermaillard reactionalcoholic liver damageliver targeting |
| spellingShingle | Xinyi Liu Yukun Song Shasha Cheng Mingqian Tan Curcumin delivery nanoparticles based on Maillard reaction of Haematococcus pluvialis protein/galactose for alleviating acute alcoholic liver damage Food Science and Human Wellness haematococcus pluvialis protein galactose curcumin nanocarrier maillard reaction alcoholic liver damage liver targeting |
| title | Curcumin delivery nanoparticles based on Maillard reaction of Haematococcus pluvialis protein/galactose for alleviating acute alcoholic liver damage |
| title_full | Curcumin delivery nanoparticles based on Maillard reaction of Haematococcus pluvialis protein/galactose for alleviating acute alcoholic liver damage |
| title_fullStr | Curcumin delivery nanoparticles based on Maillard reaction of Haematococcus pluvialis protein/galactose for alleviating acute alcoholic liver damage |
| title_full_unstemmed | Curcumin delivery nanoparticles based on Maillard reaction of Haematococcus pluvialis protein/galactose for alleviating acute alcoholic liver damage |
| title_short | Curcumin delivery nanoparticles based on Maillard reaction of Haematococcus pluvialis protein/galactose for alleviating acute alcoholic liver damage |
| title_sort | curcumin delivery nanoparticles based on maillard reaction of haematococcus pluvialis protein galactose for alleviating acute alcoholic liver damage |
| topic | haematococcus pluvialis protein galactose curcumin nanocarrier maillard reaction alcoholic liver damage liver targeting |
| url | https://www.sciopen.com/article/10.26599/FSHW.2022.9250211 |
| work_keys_str_mv | AT xinyiliu curcumindeliverynanoparticlesbasedonmaillardreactionofhaematococcuspluvialisproteingalactoseforalleviatingacutealcoholicliverdamage AT yukunsong curcumindeliverynanoparticlesbasedonmaillardreactionofhaematococcuspluvialisproteingalactoseforalleviatingacutealcoholicliverdamage AT shashacheng curcumindeliverynanoparticlesbasedonmaillardreactionofhaematococcuspluvialisproteingalactoseforalleviatingacutealcoholicliverdamage AT mingqiantan curcumindeliverynanoparticlesbasedonmaillardreactionofhaematococcuspluvialisproteingalactoseforalleviatingacutealcoholicliverdamage |