Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil
ABSTRACT Introduction: Narcolepsy patients have higher prevalence of comorbidities, such as obesity, depression, and pain. Narcolepsy symptoms and concomitant medical conditions can impact the daily activities of patients. The objective of this study is to describe the quality of life in a sample...
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Thieme Revinter Publicações
2020-06-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000800488&tlng=en |
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| author | Renata Carvalho CREMASCHI Camila HIROTSU Sergio TUFIK Fernando Morgadinho COELHO |
| author_facet | Renata Carvalho CREMASCHI Camila HIROTSU Sergio TUFIK Fernando Morgadinho COELHO |
| author_sort | Renata Carvalho CREMASCHI |
| collection | DOAJ |
| description | ABSTRACT Introduction: Narcolepsy patients have higher prevalence of comorbidities, such as obesity, depression, and pain. Narcolepsy symptoms and concomitant medical conditions can impact the daily activities of patients. The objective of this study is to describe the quality of life in a sample of patients with narcolepsy, and the influence of the nutritional status in health domains. Methods: At Unifesp, two groups of 33 patients (narcolepsy types 1 and 2 meeting 2014 criteria, concerning hypocretin-1) and 33 controls without sleepiness, matched by age and sex, filled out the SF-36. Results: Narcolepsy groups, regardless of their nutritional status, had significantly lower scores in all domains, compared to controls, mainly in Role-physical, Role-emotional, and Energy/Fatigue. Role-physical score was lower in type 1 than in type 2 and controls (37.8±1.0 vs. 50.0±1.2 vs. 85.6±1.6; p<0.0001). Obese with type 2 narcolepsy scored lower than type 1 in physical scales. Conclusion: In a Sleep Center in São Paulo, Brazil, physical and mental health were impaired in narcolepsy types 1 and 2. The first report of the poor health status in Brazilians with narcolepsy type 2 suggests that obesity negatively affects physical domains. |
| format | Article |
| id | doaj-art-de4400a476c0428290e4126851ac5453 |
| institution | Kabale University |
| issn | 1678-4227 |
| language | English |
| publishDate | 2020-06-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-de4400a476c0428290e4126851ac54532025-08-20T03:24:40ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria1678-42272020-06-0178848849310.1590/0004-282x20200032Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in BrazilRenata Carvalho CREMASCHIhttps://orcid.org/0000-0002-8205-4816Camila HIROTSUhttps://orcid.org/0000-0002-6760-0663Sergio TUFIKhttps://orcid.org/0000-0002-4012-4951Fernando Morgadinho COELHOhttps://orcid.org/0000-0002-8482-3754ABSTRACT Introduction: Narcolepsy patients have higher prevalence of comorbidities, such as obesity, depression, and pain. Narcolepsy symptoms and concomitant medical conditions can impact the daily activities of patients. The objective of this study is to describe the quality of life in a sample of patients with narcolepsy, and the influence of the nutritional status in health domains. Methods: At Unifesp, two groups of 33 patients (narcolepsy types 1 and 2 meeting 2014 criteria, concerning hypocretin-1) and 33 controls without sleepiness, matched by age and sex, filled out the SF-36. Results: Narcolepsy groups, regardless of their nutritional status, had significantly lower scores in all domains, compared to controls, mainly in Role-physical, Role-emotional, and Energy/Fatigue. Role-physical score was lower in type 1 than in type 2 and controls (37.8±1.0 vs. 50.0±1.2 vs. 85.6±1.6; p<0.0001). Obese with type 2 narcolepsy scored lower than type 1 in physical scales. Conclusion: In a Sleep Center in São Paulo, Brazil, physical and mental health were impaired in narcolepsy types 1 and 2. The first report of the poor health status in Brazilians with narcolepsy type 2 suggests that obesity negatively affects physical domains.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000800488&tlng=enNarcolepsyHypocretin-1Quality of LifeObesity |
| spellingShingle | Renata Carvalho CREMASCHI Camila HIROTSU Sergio TUFIK Fernando Morgadinho COELHO Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil Arquivos de Neuro-Psiquiatria Narcolepsy Hypocretin-1 Quality of Life Obesity |
| title | Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil |
| title_full | Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil |
| title_fullStr | Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil |
| title_full_unstemmed | Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil |
| title_short | Health-related quality of life in patients with narcolepsy types 1 and 2 from a Sleep Center in Brazil |
| title_sort | health related quality of life in patients with narcolepsy types 1 and 2 from a sleep center in brazil |
| topic | Narcolepsy Hypocretin-1 Quality of Life Obesity |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-282X2020000800488&tlng=en |
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