The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature Review
Sarcopenia is a geriatric syndrome characterized by decline of skeletal muscle mass and function. Contributing factors include nutritional, genetic, inflammatory, and endocrinal factors. The reported prevalence of sarcopenia in type 2 diabetes mellitus is high, especially in patients with poor glyce...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
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| Series: | Journal of Diabetes Research |
| Online Access: | http://dx.doi.org/10.1155/2020/9368583 |
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| _version_ | 1832554598792953856 |
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| author | Chen-Ning Wu Kai-Jen Tien |
| author_facet | Chen-Ning Wu Kai-Jen Tien |
| author_sort | Chen-Ning Wu |
| collection | DOAJ |
| description | Sarcopenia is a geriatric syndrome characterized by decline of skeletal muscle mass and function. Contributing factors include nutritional, genetic, inflammatory, and endocrinal factors. The reported prevalence of sarcopenia in type 2 diabetes mellitus is high, especially in patients with poor glycemic control. Additionally, antidiabetic agents may alter the balance between protein synthesis and degradation through various mechanisms of skeletal muscle mass regulation. This study reviewed the literature on the pathogenesis of sarcopenia in diabetes mellitus and the current understanding of whether antidiabetic agents contribute positively or negatively to sarcopenia and muscle wasting. |
| format | Article |
| id | doaj-art-de4253addb8b4e5495471e4e11779b7e |
| institution | Kabale University |
| issn | 2314-6745 2314-6753 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Diabetes Research |
| spelling | doaj-art-de4253addb8b4e5495471e4e11779b7e2025-02-03T05:51:14ZengWileyJournal of Diabetes Research2314-67452314-67532020-01-01202010.1155/2020/93685839368583The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature ReviewChen-Ning Wu0Kai-Jen Tien1Department of Internal Medicine, Chi Mei Medical Center, Tainan, TaiwanDivision of Endocrinology and Metabolism, Department of Internal Medicine, Chi Mei Medical Center, Tainan, TaiwanSarcopenia is a geriatric syndrome characterized by decline of skeletal muscle mass and function. Contributing factors include nutritional, genetic, inflammatory, and endocrinal factors. The reported prevalence of sarcopenia in type 2 diabetes mellitus is high, especially in patients with poor glycemic control. Additionally, antidiabetic agents may alter the balance between protein synthesis and degradation through various mechanisms of skeletal muscle mass regulation. This study reviewed the literature on the pathogenesis of sarcopenia in diabetes mellitus and the current understanding of whether antidiabetic agents contribute positively or negatively to sarcopenia and muscle wasting.http://dx.doi.org/10.1155/2020/9368583 |
| spellingShingle | Chen-Ning Wu Kai-Jen Tien The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature Review Journal of Diabetes Research |
| title | The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature Review |
| title_full | The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature Review |
| title_fullStr | The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature Review |
| title_full_unstemmed | The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature Review |
| title_short | The Impact of Antidiabetic Agents on Sarcopenia in Type 2 Diabetes: A Literature Review |
| title_sort | impact of antidiabetic agents on sarcopenia in type 2 diabetes a literature review |
| url | http://dx.doi.org/10.1155/2020/9368583 |
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