Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology
In nature, plants defend themselves against pathogen attack by activating an arsenal of defense mechanisms. During the last decades, work mainly focused on the understanding of qualitative disease resistance mediated by a few genes conferring an almost complete resistance, while quantitative disease...
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Académie des sciences
2024-05-01
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| Series: | Comptes Rendus Biologies |
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| Online Access: | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.153/ |
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| author | Chauveau, Carine Roby, Dominique |
| author_facet | Chauveau, Carine Roby, Dominique |
| author_sort | Chauveau, Carine |
| collection | DOAJ |
| description | In nature, plants defend themselves against pathogen attack by activating an arsenal of defense mechanisms. During the last decades, work mainly focused on the understanding of qualitative disease resistance mediated by a few genes conferring an almost complete resistance, while quantitative disease resistance (QDR) remains poorly understood despite the fact that it represents the predominant and more durable form of resistance in natural populations and crops. Here, we review our past and present work on the dissection of the complex mechanisms underlying QDR in Arabidopsis thaliana. The strategies, main steps and challenges of our studies related to one atypical QDR gene, RKS1 (Resistance related KinaSe 1), are presented. First, from genetic analyses by QTL (Quantitative Trait Locus) mapping and GWAs (Genome Wide Association studies), the identification, cloning and functional analysis of this gene have been used as a starting point for the exploration of the multiple and coordinated pathways acting together to mount the QDR response dependent on RKS1. Identification of RKS1 protein interactors and complexes was a first step, systems biology and reconstruction of protein networks were then used to decipher the molecular roadmap to the immune responses controlled by RKS1. Finally, exploration of the potential impact of key components of the RKS1-dependent gene network on leaf microbiota offers interesting and challenging perspectives to decipher how the plant immune systems interact with the microbial communities’ systems. |
| format | Article |
| id | doaj-art-de3ea82bf20d48d3874b431f49c41cfc |
| institution | Kabale University |
| issn | 1768-3238 |
| language | English |
| publishDate | 2024-05-01 |
| publisher | Académie des sciences |
| record_format | Article |
| series | Comptes Rendus Biologies |
| spelling | doaj-art-de3ea82bf20d48d3874b431f49c41cfc2025-02-07T10:37:47ZengAcadémie des sciencesComptes Rendus Biologies1768-32382024-05-01347G1354410.5802/crbiol.15310.5802/crbiol.153Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biologyChauveau, Carine0Roby, Dominique1https://orcid.org/0000-0001-8414-1799Laboratoire des Interactions Plantes-Microbes-Environnement (LIPME), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CNRS, Université de Toulouse, 31326 Castanet-Tolosan, FranceLaboratoire des Interactions Plantes-Microbes-Environnement (LIPME), Institut National de Recherche pour l’Agriculture, l’Alimentation et l’Environnement (INRAE), CNRS, Université de Toulouse, 31326 Castanet-Tolosan, FranceIn nature, plants defend themselves against pathogen attack by activating an arsenal of defense mechanisms. During the last decades, work mainly focused on the understanding of qualitative disease resistance mediated by a few genes conferring an almost complete resistance, while quantitative disease resistance (QDR) remains poorly understood despite the fact that it represents the predominant and more durable form of resistance in natural populations and crops. Here, we review our past and present work on the dissection of the complex mechanisms underlying QDR in Arabidopsis thaliana. The strategies, main steps and challenges of our studies related to one atypical QDR gene, RKS1 (Resistance related KinaSe 1), are presented. First, from genetic analyses by QTL (Quantitative Trait Locus) mapping and GWAs (Genome Wide Association studies), the identification, cloning and functional analysis of this gene have been used as a starting point for the exploration of the multiple and coordinated pathways acting together to mount the QDR response dependent on RKS1. Identification of RKS1 protein interactors and complexes was a first step, systems biology and reconstruction of protein networks were then used to decipher the molecular roadmap to the immune responses controlled by RKS1. Finally, exploration of the potential impact of key components of the RKS1-dependent gene network on leaf microbiota offers interesting and challenging perspectives to decipher how the plant immune systems interact with the microbial communities’ systems.https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.153/Plant–pathogen interactionsImmunityQuantitative disease resistance (QDR)Protein–protein interactionsNetworksSignalingMicrobiota |
| spellingShingle | Chauveau, Carine Roby, Dominique Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology Comptes Rendus Biologies Plant–pathogen interactions Immunity Quantitative disease resistance (QDR) Protein–protein interactions Networks Signaling Microbiota |
| title | Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology |
| title_full | Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology |
| title_fullStr | Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology |
| title_full_unstemmed | Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology |
| title_short | Molecular complexity of quantitative immunity in plants: from QTL mapping to functional and systems biology |
| title_sort | molecular complexity of quantitative immunity in plants from qtl mapping to functional and systems biology |
| topic | Plant–pathogen interactions Immunity Quantitative disease resistance (QDR) Protein–protein interactions Networks Signaling Microbiota |
| url | https://comptes-rendus.academie-sciences.fr/biologies/articles/10.5802/crbiol.153/ |
| work_keys_str_mv | AT chauveaucarine molecularcomplexityofquantitativeimmunityinplantsfromqtlmappingtofunctionalandsystemsbiology AT robydominique molecularcomplexityofquantitativeimmunityinplantsfromqtlmappingtofunctionalandsystemsbiology |