A hypomorphic model of CPS1 deficiency for investigating the effects of hyperammonemia on the developing nervous system
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| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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The Company of Biologists
2025-07-01
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| Series: | Disease Models & Mechanisms |
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| Online Access: | http://dmm.biologists.org/content/18/7/dmm052303 |
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| author | Stuti Bakshi Taryn Diep Brandon J. Willis Rachel Reyes Grace F. Wu Georgios Makris Martin Poms Isabel Day Qin Sun Irina Zhuravka Lindsay Lueptow Michelle Tang Gareth A. Cromie Aimée M. Dudley Johannes Häberle Gerald S. Lipshutz |
| author_facet | Stuti Bakshi Taryn Diep Brandon J. Willis Rachel Reyes Grace F. Wu Georgios Makris Martin Poms Isabel Day Qin Sun Irina Zhuravka Lindsay Lueptow Michelle Tang Gareth A. Cromie Aimée M. Dudley Johannes Häberle Gerald S. Lipshutz |
| author_sort | Stuti Bakshi |
| collection | DOAJ |
| format | Article |
| id | doaj-art-de39ddbfe4774f6bbe697aa35d6fc4d4 |
| institution | Kabale University |
| issn | 1754-8403 1754-8411 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | The Company of Biologists |
| record_format | Article |
| series | Disease Models & Mechanisms |
| spelling | doaj-art-de39ddbfe4774f6bbe697aa35d6fc4d42025-08-20T03:41:21ZengThe Company of BiologistsDisease Models & Mechanisms1754-84031754-84112025-07-0118710.1242/dmm.052303052303A hypomorphic model of CPS1 deficiency for investigating the effects of hyperammonemia on the developing nervous systemStuti Bakshi0Taryn Diep1Brandon J. Willis2Rachel Reyes3Grace F. Wu4Georgios Makris5Martin Poms6Isabel Day7Qin Sun8Irina Zhuravka9Lindsay Lueptow10Michelle Tang11Gareth A. Cromie12Aimée M. Dudley13Johannes Häberle14Gerald S. Lipshutz15 Departments of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA Departments of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA Mouse Biology Program, University of California, Davis, Davis, CA 95618, USA Departments of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA Departments of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich 8008, Switzerland Clinical Chemistry and Biochemistry, University Children's Hospital Zurich, Zurich 8008, Switzerland Departments of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA Department of Psychology, UCLA, Los Angeles, CA 90095, USA Department of Psychology, UCLA, Los Angeles, CA 90095, USA Pacific Northwest Research Institute, Seattle, WA 98122, USA Pacific Northwest Research Institute, Seattle, WA 98122, USA Pacific Northwest Research Institute, Seattle, WA 98122, USA Division of Metabolism and Children's Research Center, University Children's Hospital Zurich, Zurich 8008, Switzerland Departments of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA http://dmm.biologists.org/content/18/7/dmm052303carbamoyl phosphate synthetase 1 deficiencyhuman mutationenzyme activityhyperammonemiaglutamine |
| spellingShingle | Stuti Bakshi Taryn Diep Brandon J. Willis Rachel Reyes Grace F. Wu Georgios Makris Martin Poms Isabel Day Qin Sun Irina Zhuravka Lindsay Lueptow Michelle Tang Gareth A. Cromie Aimée M. Dudley Johannes Häberle Gerald S. Lipshutz A hypomorphic model of CPS1 deficiency for investigating the effects of hyperammonemia on the developing nervous system Disease Models & Mechanisms carbamoyl phosphate synthetase 1 deficiency human mutation enzyme activity hyperammonemia glutamine |
| title | A hypomorphic model of CPS1 deficiency for investigating the effects of hyperammonemia on the developing nervous system |
| title_full | A hypomorphic model of CPS1 deficiency for investigating the effects of hyperammonemia on the developing nervous system |
| title_fullStr | A hypomorphic model of CPS1 deficiency for investigating the effects of hyperammonemia on the developing nervous system |
| title_full_unstemmed | A hypomorphic model of CPS1 deficiency for investigating the effects of hyperammonemia on the developing nervous system |
| title_short | A hypomorphic model of CPS1 deficiency for investigating the effects of hyperammonemia on the developing nervous system |
| title_sort | hypomorphic model of cps1 deficiency for investigating the effects of hyperammonemia on the developing nervous system |
| topic | carbamoyl phosphate synthetase 1 deficiency human mutation enzyme activity hyperammonemia glutamine |
| url | http://dmm.biologists.org/content/18/7/dmm052303 |
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