Selective Mapping of Brain COX-1 with [11C]PS13: Pharmacokinetic Evidence from human PET Imaging

Selective Mapping of Brain COX-1 with [11C]PS13: Pharmacokinetic Evidence from human PET Imaging

Background and aim: Arachidonic acid is converted by cyclooxygenase-1 (COX-1) and cyclooxygenase-2 (COX-2) to prostaglandin H2, which has proinflammatory properties. The new PET radioligand [11 C]PS13 exhibits superior in vivo selectivity for COX-1 in nonhuman primates compared to COX-2. This study...

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Main Authors: Kiana Orangi, Kimiya Batebi, Farnoosh Vosough, Mahdiyeh Nozad Varjovi, Fatemeh Salehian, Sahar Mesbah, Mehrnaz Salahi, Sajjad Hajihosseini, Mohammad Yousef Fazel, Saman Zaman, Reza Hossein Zadeh, Alaleh Alizadeh, Mahsa Asadi Anar, Niloofar Deravi
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:IBRO Neuroscience Reports
Subjects:
Cyclooxygenase-1 (COX-1)
PET imaging
Neuroinflammation
[11 C]PS13
NSAIDs
COX-selectivity
Online Access:http://www.sciencedirect.com/science/article/pii/S2667242125000594
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