CAMTA1-immunonegative epithelioid hemangioendotheliomas of the liver: a clinicopathological and molecular analysis of seven cases

CAMTA1-immunonegative epithelioid hemangioendotheliomas of the liver: a clinicopathological and molecular analysis of seven cases

BackgroundEpithelioid hemangioendothelioma (EHE) is a rare malignant vascular tumor. Most EHEs (>90%) cases harbor WWTR1::CAMTA1 fusion gene, and CAMTA1 immunohistochemistry (IHC) is a highly sensitive and specific tool for EHE diagnosis. However, there exist CAMTA1-immunonegative cases, the...

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Bibliographic Details
Main Authors: Yang Nie, Wenyi Jing, Xuanxuan Zheng, Xin He, Min Chen, Hongying Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Oncology
Subjects:
epithelioid hemangioendothelioma
liver tumor
WWTR1::CAMTA1 fusion gene
YAP1::TFE3 fusion gene
molecular analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1478036/full
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