Oxidative Stress Level in the Testes of Mice and Rats during Nickel Intoxication
The genotioxic and carcinogenic effect of nickel probably results from its capacity to produce reactive oxygen species (ROS) and disturb the redox balance. The aim of the study was to find out if rats lacking spermatic protamine 2 are less susceptible to Ni(II) than mice. Consequently, the levels of...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/395741 |
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| author | Eugenia Murawska-Ciałowicz Wojciech Bal Lidia Januszewska Marcin Zawadzki Joanna Rychel Jolanta Zuwała-Jagiełło |
| author_facet | Eugenia Murawska-Ciałowicz Wojciech Bal Lidia Januszewska Marcin Zawadzki Joanna Rychel Jolanta Zuwała-Jagiełło |
| author_sort | Eugenia Murawska-Ciałowicz |
| collection | DOAJ |
| description | The genotioxic and carcinogenic effect of nickel probably results from its capacity to produce reactive oxygen species (ROS) and disturb the redox balance. The aim of the study was to find out if rats lacking spermatic protamine 2 are less susceptible to Ni(II) than mice. Consequently, the levels of malondialdehyde + 4 hydroxynonenal (MDA+4HDA) − markers of lipid peroxidation, as well as the level of reduced glutathione (GSH) were measured within the rat and mouse testes. Our results showed that the levels of lipid peroxidation markers were elevated in testicular homogenates of intoxicated mice without any changes in rats. GSH level was lower in the group of intoxicated mice comparing to the control without statistically significant changes in rats’ homogenates. Moreover, the level of GSH in the testes of intoxicated mice was lower than in rats. On the basis of our results, it appears that Ni(II) can initiate oxidative stress in the testes of mice but not of rats and can reduce GSH level. Consequently, the antioxidative defense of the testes is reduced. Ni(II) that causes oxidative stress in the testes may also contribute to infertility. |
| format | Article |
| id | doaj-art-de2f6616ca39425a9266c581acf68fab |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-de2f6616ca39425a9266c581acf68fab2025-02-03T06:45:27ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/395741395741Oxidative Stress Level in the Testes of Mice and Rats during Nickel IntoxicationEugenia Murawska-Ciałowicz0Wojciech Bal1Lidia Januszewska2Marcin Zawadzki3Joanna Rychel4Jolanta Zuwała-Jagiełło5Physiology and Biochemistry Department, University of Physical Education, Avenue I.J. Paderewskiego 35, 51-612 Wroclaw, PolandBiochemistry and Biophysic Institute, Polish Academy of Sciences, Ul. Pawińskiego 5a, 02-106 Warsaw, PolandHygiene Department, Medical University, Ul. J. Mikulicza-Radeckiego 7, 50-368 Wroclaw, PolandForensic Medicine Department, Medical University, Ul. Mikulicza-Radeckiego 4, 50-368 Wroclaw, PolandHygiene Department, Medical University, Ul. J. Mikulicza-Radeckiego 7, 50-368 Wroclaw, PolandPharmaceutical Biochemistry Department, Medical University, ul. Szewska 38/39, 50-139 Wroclaw, PolandThe genotioxic and carcinogenic effect of nickel probably results from its capacity to produce reactive oxygen species (ROS) and disturb the redox balance. The aim of the study was to find out if rats lacking spermatic protamine 2 are less susceptible to Ni(II) than mice. Consequently, the levels of malondialdehyde + 4 hydroxynonenal (MDA+4HDA) − markers of lipid peroxidation, as well as the level of reduced glutathione (GSH) were measured within the rat and mouse testes. Our results showed that the levels of lipid peroxidation markers were elevated in testicular homogenates of intoxicated mice without any changes in rats. GSH level was lower in the group of intoxicated mice comparing to the control without statistically significant changes in rats’ homogenates. Moreover, the level of GSH in the testes of intoxicated mice was lower than in rats. On the basis of our results, it appears that Ni(II) can initiate oxidative stress in the testes of mice but not of rats and can reduce GSH level. Consequently, the antioxidative defense of the testes is reduced. Ni(II) that causes oxidative stress in the testes may also contribute to infertility.http://dx.doi.org/10.1100/2012/395741 |
| spellingShingle | Eugenia Murawska-Ciałowicz Wojciech Bal Lidia Januszewska Marcin Zawadzki Joanna Rychel Jolanta Zuwała-Jagiełło Oxidative Stress Level in the Testes of Mice and Rats during Nickel Intoxication The Scientific World Journal |
| title | Oxidative Stress Level in the Testes of Mice and Rats during Nickel Intoxication |
| title_full | Oxidative Stress Level in the Testes of Mice and Rats during Nickel Intoxication |
| title_fullStr | Oxidative Stress Level in the Testes of Mice and Rats during Nickel Intoxication |
| title_full_unstemmed | Oxidative Stress Level in the Testes of Mice and Rats during Nickel Intoxication |
| title_short | Oxidative Stress Level in the Testes of Mice and Rats during Nickel Intoxication |
| title_sort | oxidative stress level in the testes of mice and rats during nickel intoxication |
| url | http://dx.doi.org/10.1100/2012/395741 |
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