Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease

Multi-omics derivation of a core gene signature for predicting therapeutic response and characterizing immune dysregulation in inflammatory bowel disease

BackgroundInflammatory bowel disease (IBD) presents unpredictable therapeutic responses and complex immune dysregulation. Current precision medicine approaches lack robust molecular tools integrating transcriptomic signatures with immune dynamics for personalized treatment guidance.MethodsWe perform...

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Bibliographic Details
Main Authors: Mingming Wang, Liping Liang, Zibo Tang, Jimin Han, Lele Wu, Le Liu, Ye Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
inflammatory bowel disease
machine learning
immune infiltration
biologic response prediction
precision medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1611598/full
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