Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid
Purpose. To describe tumor shrinkage of nonirradiated lung metastases in a patient with non-small cell lung cancer. Case Report. The patient had a concurrent autoimmune condition, bullous pemphigoid, which was clinically exacerbated during radiotherapy of mediastinal and axillary lymph node metastas...
Saved in:
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Case Reports in Oncological Medicine |
| Online Access: | http://dx.doi.org/10.1155/2015/964687 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849435195325808640 |
|---|---|
| author | Carsten Nieder Khalid Al-Shibli Terje Tollåli |
| author_facet | Carsten Nieder Khalid Al-Shibli Terje Tollåli |
| author_sort | Carsten Nieder |
| collection | DOAJ |
| description | Purpose. To describe tumor shrinkage of nonirradiated lung metastases in a patient with non-small cell lung cancer. Case Report. The patient had a concurrent autoimmune condition, bullous pemphigoid, which was clinically exacerbated during radiotherapy of mediastinal and axillary lymph node metastases. He also developed a series of infections during and after irradiation, and we hypothesize that the immunological events during this phase might have influenced the size of the nonirradiated metastases. Conclusion. Ionizing radiation generates inflammatory signals and, in principle, could provide both tumor-specific antigens from dying cells and maturation stimuli that are necessary for dendritic cells’ activation of tumor-specific T cells. Even if the detailed mechanisms causing nontargeted immune modulatory effects in individual patients are poorly understood, clinical development of radioimmunotherapy is underway. |
| format | Article |
| id | doaj-art-de2e41564cf84df29d566f59a842fbcf |
| institution | Kabale University |
| issn | 2090-6706 2090-6714 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Oncological Medicine |
| spelling | doaj-art-de2e41564cf84df29d566f59a842fbcf2025-08-20T03:26:21ZengWileyCase Reports in Oncological Medicine2090-67062090-67142015-01-01201510.1155/2015/964687964687Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous PemphigoidCarsten Nieder0Khalid Al-Shibli1Terje Tollåli2Department of Oncology and Palliative Medicine, Nordland Hospital, 8092 Bodø, NorwayDepartment of Pathology, Nordland Hospital, 8092 Bodø, NorwayDepartment of Pulmonology, Nordland Hospital, 8092 Bodø, NorwayPurpose. To describe tumor shrinkage of nonirradiated lung metastases in a patient with non-small cell lung cancer. Case Report. The patient had a concurrent autoimmune condition, bullous pemphigoid, which was clinically exacerbated during radiotherapy of mediastinal and axillary lymph node metastases. He also developed a series of infections during and after irradiation, and we hypothesize that the immunological events during this phase might have influenced the size of the nonirradiated metastases. Conclusion. Ionizing radiation generates inflammatory signals and, in principle, could provide both tumor-specific antigens from dying cells and maturation stimuli that are necessary for dendritic cells’ activation of tumor-specific T cells. Even if the detailed mechanisms causing nontargeted immune modulatory effects in individual patients are poorly understood, clinical development of radioimmunotherapy is underway.http://dx.doi.org/10.1155/2015/964687 |
| spellingShingle | Carsten Nieder Khalid Al-Shibli Terje Tollåli Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid Case Reports in Oncological Medicine |
| title | Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid |
| title_full | Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid |
| title_fullStr | Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid |
| title_full_unstemmed | Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid |
| title_short | Nontargeted Effect after Radiotherapy in a Patient with Non-Small Cell Lung Cancer and Bullous Pemphigoid |
| title_sort | nontargeted effect after radiotherapy in a patient with non small cell lung cancer and bullous pemphigoid |
| url | http://dx.doi.org/10.1155/2015/964687 |
| work_keys_str_mv | AT carstennieder nontargetedeffectafterradiotherapyinapatientwithnonsmallcelllungcancerandbullouspemphigoid AT khalidalshibli nontargetedeffectafterradiotherapyinapatientwithnonsmallcelllungcancerandbullouspemphigoid AT terjetollali nontargetedeffectafterradiotherapyinapatientwithnonsmallcelllungcancerandbullouspemphigoid |