Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects

Antisense oligonucleotide targeting nicotinamide N-methyltransferase exhibits antitumor effects

Nicotinamide N-methyltransferase (NNMT) is one of the methyltransferase family genes. It consumes S-adenosyl-l-methionine (SAM), which is required for DNA methylation and histone methylation for epigenetic regulation, to produce 1-methylnicotinamide from nicotinamide, a source of NAD+, thus affectin...

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Bibliographic Details
Main Authors: Tomoaki Hara, Sikun Meng, Yuuya Kasahara, Takashi Osawa, Daisuke Motooka, Hiromichi Sato, Yasuko Arao, Yoshiko Saito, Kana Inoue, Yumiko Hamano, Yuichiro Doki, Hidetoshi Eguchi, Satoshi Obika, Hideshi Ishii
Format: Article
Language:English
Published: Elsevier 2025-06-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
MT: Oligonucleotides: Therapies and Applications
antisense oligonucleotide
NNMT
FAP
BNA/LNA
FAP-binding small-molecule-conjugated ASO and antitumor
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253125001027
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