Actionable heterogeneity of hepatocellular carcinoma therapy-induced senescence

Actionable heterogeneity of hepatocellular carcinoma therapy-induced senescence

Abstract Therapy-induced senescence (TIS) is a stable cell cycle arrest in cancerous cells favoring immune control upon immune cell recruitment and activation via a senescence-associated secretory phenotype (SASP). Numerous studies have investigated the therapeutic applicability of TIS in hepatocell...

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Main Authors: Pujan Engels, Andras Szolek, Sebastian Hörner, Georgios Vavouras Syrigos, Kim Hebbel, Michelle Schmidtke, Min Zhou, Maria Mateo-Tortola, Caroline Schönfeld, Sylwia Anna Stefanczyk, Katharina Wolter, Sepideh Babaei, Michael Schindler, Manfred Claassen, Daniel Dauch, Lars Zender, Ana Tapía-Abellán, Alexander N. R. Weber
Format: Article
Language:English
Published: Springer 2025-05-01
Series:Cancer Immunology, Immunotherapy
Subjects:
Senescence
Hepatocellular carcinoma
Immunotherapy
Immunology
Online Access:https://doi.org/10.1007/s00262-025-04060-w
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