Mechanisms of Action of Topical Corticosteroids in Psoriasis
Psoriasis is a lifelong, chronic, and immune-mediated systemic disease, which affects approximately 1–3% of the Caucasian population. The different presentations of psoriasis require different approaches to treatment and appropriate prescriptions according to disease severity. The use of topical the...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/561018 |
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| _version_ | 1832556225254916096 |
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| author | Luís Uva Diana Miguel Catarina Pinheiro Joana Antunes Diogo Cruz João Ferreira Paulo Filipe |
| author_facet | Luís Uva Diana Miguel Catarina Pinheiro Joana Antunes Diogo Cruz João Ferreira Paulo Filipe |
| author_sort | Luís Uva |
| collection | DOAJ |
| description | Psoriasis is a lifelong, chronic, and immune-mediated systemic disease, which affects approximately 1–3% of the Caucasian population. The different presentations of psoriasis require different approaches to treatment and appropriate prescriptions according to disease severity. The use of topical therapy remains a key component of the management of almost all psoriasis patients, and while mild disease is commonly treated only with topical agents, the use of topical therapy as adjuvant therapy in moderate-to-severe disease may also be helpful. This paper focuses on the cutaneous mechanisms of action of corticosteroids and on the currently available topical treatments, taking into account adverse effects, bioavailability, new combination treatments, and strategies to improve the safety of corticosteroids. It is established that the treatment choice should be tailored to match the individual patient’s needs and his/her expectations, prescribing to each patient the most suitable vehicle. |
| format | Article |
| id | doaj-art-de25890f2f96497ebcd0bba6031e161a |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-de25890f2f96497ebcd0bba6031e161a2025-02-03T05:46:09ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/561018561018Mechanisms of Action of Topical Corticosteroids in PsoriasisLuís Uva0Diana Miguel1Catarina Pinheiro2Joana Antunes3Diogo Cruz4João Ferreira5Paulo Filipe6Clínica Universitária de Dermatologia, Faculdade de Medicina de Lisboa, Av. Professor Egas Moniz, 1649-035 Lisbon, PortugalClínica Universitária de Dermatologia, Faculdade de Medicina de Lisboa, Av. Professor Egas Moniz, 1649-035 Lisbon, PortugalClínica Universitária de Dermatologia, Faculdade de Medicina de Lisboa, Av. Professor Egas Moniz, 1649-035 Lisbon, PortugalClínica Universitária de Dermatologia, Faculdade de Medicina de Lisboa, Av. Professor Egas Moniz, 1649-035 Lisbon, PortugalClínica Universitária de Dermatologia, Faculdade de Medicina de Lisboa, Av. Professor Egas Moniz, 1649-035 Lisbon, PortugalClínica Universitária de Dermatologia, Faculdade de Medicina de Lisboa, Av. Professor Egas Moniz, 1649-035 Lisbon, PortugalClínica Universitária de Dermatologia, Faculdade de Medicina de Lisboa, Av. Professor Egas Moniz, 1649-035 Lisbon, PortugalPsoriasis is a lifelong, chronic, and immune-mediated systemic disease, which affects approximately 1–3% of the Caucasian population. The different presentations of psoriasis require different approaches to treatment and appropriate prescriptions according to disease severity. The use of topical therapy remains a key component of the management of almost all psoriasis patients, and while mild disease is commonly treated only with topical agents, the use of topical therapy as adjuvant therapy in moderate-to-severe disease may also be helpful. This paper focuses on the cutaneous mechanisms of action of corticosteroids and on the currently available topical treatments, taking into account adverse effects, bioavailability, new combination treatments, and strategies to improve the safety of corticosteroids. It is established that the treatment choice should be tailored to match the individual patient’s needs and his/her expectations, prescribing to each patient the most suitable vehicle.http://dx.doi.org/10.1155/2012/561018 |
| spellingShingle | Luís Uva Diana Miguel Catarina Pinheiro Joana Antunes Diogo Cruz João Ferreira Paulo Filipe Mechanisms of Action of Topical Corticosteroids in Psoriasis International Journal of Endocrinology |
| title | Mechanisms of Action of Topical Corticosteroids in Psoriasis |
| title_full | Mechanisms of Action of Topical Corticosteroids in Psoriasis |
| title_fullStr | Mechanisms of Action of Topical Corticosteroids in Psoriasis |
| title_full_unstemmed | Mechanisms of Action of Topical Corticosteroids in Psoriasis |
| title_short | Mechanisms of Action of Topical Corticosteroids in Psoriasis |
| title_sort | mechanisms of action of topical corticosteroids in psoriasis |
| url | http://dx.doi.org/10.1155/2012/561018 |
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