Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research
Coronavirus epidemics have posed a serious threat to both human and animal health. To combat emerging infectious diseases caused by coronaviruses, various animal infection models have been developed and applied in research, including non-human primate models, ferret models, hamster models, mouse mod...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-01-01
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| Series: | Viruses |
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| Online Access: | https://www.mdpi.com/1999-4915/17/1/100 |
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| _version_ | 1832587321271123968 |
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| author | Fenglian Xiao Jincheng Hu Minsheng Xu Di Wang Xiaoyan Shen Hua Zhang Jie Miao Haodong Cai Jihui Wang Yaqing Liu Shan Xiao Longchao Zhu |
| author_facet | Fenglian Xiao Jincheng Hu Minsheng Xu Di Wang Xiaoyan Shen Hua Zhang Jie Miao Haodong Cai Jihui Wang Yaqing Liu Shan Xiao Longchao Zhu |
| author_sort | Fenglian Xiao |
| collection | DOAJ |
| description | Coronavirus epidemics have posed a serious threat to both human and animal health. To combat emerging infectious diseases caused by coronaviruses, various animal infection models have been developed and applied in research, including non-human primate models, ferret models, hamster models, mouse models, and others. Moreover, new approaches have been utilized to develop animal models that are more susceptible to infection. These approaches include using viral delivery methods to induce the expression of viral receptors in mouse tissues and employing gene-editing techniques to create genetically modified mice. This has led to the successful establishment of infection models for multiple coronaviruses, significantly advancing related research. In contrast, livestock and pets that can be infected by animal coronaviruses provide valuable insights when used as infection models, enabling the collection of accurate clinical data through the analysis of post-infection pathological features. However, despite the potential insights, there is a paucity of research data pertaining to these infection models. In this review, we provide a detailed overview of recent progress in the development of animal models for coronaviruses that cause diseases in both humans and animals and suggest ways in which animal models can be adapted to further enhance their value in research. |
| format | Article |
| id | doaj-art-de17c821f7b342daa31cb73cde6c1eb0 |
| institution | Kabale University |
| issn | 1999-4915 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj-art-de17c821f7b342daa31cb73cde6c1eb02025-01-24T13:52:35ZengMDPI AGViruses1999-49152025-01-0117110010.3390/v17010100Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus ResearchFenglian Xiao0Jincheng Hu1Minsheng Xu2Di Wang3Xiaoyan Shen4Hua Zhang5Jie Miao6Haodong Cai7Jihui Wang8Yaqing Liu9Shan Xiao10Longchao Zhu11School of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaSchool of Life and Health Technology, Dongguan University of Technology, Dongguan 523808, ChinaCoronavirus epidemics have posed a serious threat to both human and animal health. To combat emerging infectious diseases caused by coronaviruses, various animal infection models have been developed and applied in research, including non-human primate models, ferret models, hamster models, mouse models, and others. Moreover, new approaches have been utilized to develop animal models that are more susceptible to infection. These approaches include using viral delivery methods to induce the expression of viral receptors in mouse tissues and employing gene-editing techniques to create genetically modified mice. This has led to the successful establishment of infection models for multiple coronaviruses, significantly advancing related research. In contrast, livestock and pets that can be infected by animal coronaviruses provide valuable insights when used as infection models, enabling the collection of accurate clinical data through the analysis of post-infection pathological features. However, despite the potential insights, there is a paucity of research data pertaining to these infection models. In this review, we provide a detailed overview of recent progress in the development of animal models for coronaviruses that cause diseases in both humans and animals and suggest ways in which animal models can be adapted to further enhance their value in research.https://www.mdpi.com/1999-4915/17/1/100coronavirusanimal modelhumananimalinfectionclinical manifestations |
| spellingShingle | Fenglian Xiao Jincheng Hu Minsheng Xu Di Wang Xiaoyan Shen Hua Zhang Jie Miao Haodong Cai Jihui Wang Yaqing Liu Shan Xiao Longchao Zhu Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research Viruses coronavirus animal model human animal infection clinical manifestations |
| title | Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research |
| title_full | Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research |
| title_fullStr | Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research |
| title_full_unstemmed | Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research |
| title_short | Animal Models for Human-Pathogenic Coronavirus and Animal Coronavirus Research |
| title_sort | animal models for human pathogenic coronavirus and animal coronavirus research |
| topic | coronavirus animal model human animal infection clinical manifestations |
| url | https://www.mdpi.com/1999-4915/17/1/100 |
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