Detection of viral antigen and inflammatory mediators in fatal pediatric dengue: a study on lung immunopathogenesis

Detection of viral antigen and inflammatory mediators in fatal pediatric dengue: a study on lung immunopathogenesis

IntroductionThe dengue virus (DENV) is the etiological agent that causes dengue fever illness, an arbovirus with a major endemic potential that has become increasingly prevalent in Brazil and has already been associated with fatal cases in children. DENV has tropism for several organs, including lun...

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Main Authors: Leandro Junqueira Moragas, Laíza Vianna Arruda, Lucca de Lima Siqueira Oliveira, Felipe de Andrade Vieira Alves, Natália Gedeão Salomão, Jemima Fuentes Ribeiro da Silva, Carlos Alberto Basílio-de-Oliveira, Rodrigo Panno Basílio-de-Oliveira, Ronaldo Mohana-Borges, Caio Gonçalves Azevedo, Gabriela Xavier de Oliveira, Jorge José de Carvalho, Fernando Colonna Rosman, Marciano Viana Paes, Kíssila Rabelo
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-02-01
Series:Frontiers in Immunology
Subjects:
dengue virus
children
histopathology
lung
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1487284/full
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