Synchronous Metastasizing High-Grade Papillary Serous Carcinoma of the Fallopian Tube and Triple-Negative Primary Breast Cancer in a BRCA1 Mutation Carrier
Patients with a BRCA1 germline mutation often represent a challenge for medical healthcare, since they develop malignancies that tend to be more aggressive and which need to be addressed in multidisciplinary teams with more individualized therapies. We report a case of a 37-year-old woman with a BRC...
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MDPI AG
2025-04-01
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| author | Mihnea-Andrei Nicodin Tudor-Petru Nicodin Anca Popescu Elena Rusu Cosmin Alec Moldovan Alice Elena Munteanu Mariam Dalaty Ovidiu Vasile Nicodin |
| author_facet | Mihnea-Andrei Nicodin Tudor-Petru Nicodin Anca Popescu Elena Rusu Cosmin Alec Moldovan Alice Elena Munteanu Mariam Dalaty Ovidiu Vasile Nicodin |
| author_sort | Mihnea-Andrei Nicodin |
| collection | DOAJ |
| description | Patients with a BRCA1 germline mutation often represent a challenge for medical healthcare, since they develop malignancies that tend to be more aggressive and which need to be addressed in multidisciplinary teams with more individualized therapies. We report a case of a 37-year-old woman with a BRCA1 mutation who was diagnosed and treated for high-grade papillary serous carcinoma of the fallopian tube. Eight years later, her regular check-up imaging revealed a latero-aortic lymphadenopathy and a right breast tumor. She underwent a fine needle breast biopsy which was positive for invasive non-specific type carcinoma with negative estrogen, progesterone and Her2 receptors in immunohistochemistry tests. The patient underwent debulking surgery for metastatic lymphadenopathy, followed by chemotherapy with Carboplatin and Paclitaxel, and a modified right mastectomy with axillary lymphadenectomy. She subsequently initiated therapy with the PARP inhibitor Olaparib. No evidence of tumor recurrence was detected during the six-month postoperative follow-up period. The primary goal of this paper is to emphasize the complexity and challenges of managing patients with BRCA1 mutations who develop synchronous malignancies. This case report aims to highlight the increasing role of precision medicine and the importance of personalized, multidisciplinary therapeutic strategies, which include surgery, chemotherapy, and targeted therapies. |
| format | Article |
| id | doaj-art-de14a0724683486282e7d7c2a4c182b6 |
| institution | OA Journals |
| issn | 2392-7674 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Mind and Medical Sciences |
| spelling | doaj-art-de14a0724683486282e7d7c2a4c182b62025-08-20T02:21:10ZengMDPI AGJournal of Mind and Medical Sciences2392-76742025-04-011212010.3390/jmms12010020Synchronous Metastasizing High-Grade Papillary Serous Carcinoma of the Fallopian Tube and Triple-Negative Primary Breast Cancer in a BRCA1 Mutation CarrierMihnea-Andrei Nicodin0Tudor-Petru Nicodin1Anca Popescu2Elena Rusu3Cosmin Alec Moldovan4Alice Elena Munteanu5Mariam Dalaty6Ovidiu Vasile Nicodin7Department of Obstetrics and Gynecology, “Carol Davila” Central Military Emergency University Hospital, 010825 Bucharest, RomaniaDoctoral School of Medicine, “Carol Davila” University of Medicine and Pharmacy, 020021 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, “Carol Davila” Central Military Emergency University Hospital, 010825 Bucharest, RomaniaDepartment of Preclinical Disciplines, Faculty of Medicine, Titu Maiorescu University, 031593 Bucharest, RomaniaDepartment of Medico-Surgical and Prophylactic Sciences, Faculty of Medicine, Titu Maiorescu University, 031593 Bucharest, RomaniaDepartment of Medico-Surgical and Prophylactic Sciences, Faculty of Medicine, Titu Maiorescu University, 031593 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, “Carol Davila” Central Military Emergency University Hospital, 010825 Bucharest, RomaniaDepartment of Obstetrics and Gynecology, “Carol Davila” Central Military Emergency University Hospital, 010825 Bucharest, RomaniaPatients with a BRCA1 germline mutation often represent a challenge for medical healthcare, since they develop malignancies that tend to be more aggressive and which need to be addressed in multidisciplinary teams with more individualized therapies. We report a case of a 37-year-old woman with a BRCA1 mutation who was diagnosed and treated for high-grade papillary serous carcinoma of the fallopian tube. Eight years later, her regular check-up imaging revealed a latero-aortic lymphadenopathy and a right breast tumor. She underwent a fine needle breast biopsy which was positive for invasive non-specific type carcinoma with negative estrogen, progesterone and Her2 receptors in immunohistochemistry tests. The patient underwent debulking surgery for metastatic lymphadenopathy, followed by chemotherapy with Carboplatin and Paclitaxel, and a modified right mastectomy with axillary lymphadenectomy. She subsequently initiated therapy with the PARP inhibitor Olaparib. No evidence of tumor recurrence was detected during the six-month postoperative follow-up period. The primary goal of this paper is to emphasize the complexity and challenges of managing patients with BRCA1 mutations who develop synchronous malignancies. This case report aims to highlight the increasing role of precision medicine and the importance of personalized, multidisciplinary therapeutic strategies, which include surgery, chemotherapy, and targeted therapies.https://www.mdpi.com/2392-7674/12/1/20fallopian tube carcinomaPARP inhibitorstriple-negative invasive breast carcinomahigh-grade papillary serous carcinomabrca1 germline mutation |
| spellingShingle | Mihnea-Andrei Nicodin Tudor-Petru Nicodin Anca Popescu Elena Rusu Cosmin Alec Moldovan Alice Elena Munteanu Mariam Dalaty Ovidiu Vasile Nicodin Synchronous Metastasizing High-Grade Papillary Serous Carcinoma of the Fallopian Tube and Triple-Negative Primary Breast Cancer in a BRCA1 Mutation Carrier Journal of Mind and Medical Sciences fallopian tube carcinoma PARP inhibitors triple-negative invasive breast carcinoma high-grade papillary serous carcinoma brca1 germline mutation |
| title | Synchronous Metastasizing High-Grade Papillary Serous Carcinoma of the Fallopian Tube and Triple-Negative Primary Breast Cancer in a BRCA1 Mutation Carrier |
| title_full | Synchronous Metastasizing High-Grade Papillary Serous Carcinoma of the Fallopian Tube and Triple-Negative Primary Breast Cancer in a BRCA1 Mutation Carrier |
| title_fullStr | Synchronous Metastasizing High-Grade Papillary Serous Carcinoma of the Fallopian Tube and Triple-Negative Primary Breast Cancer in a BRCA1 Mutation Carrier |
| title_full_unstemmed | Synchronous Metastasizing High-Grade Papillary Serous Carcinoma of the Fallopian Tube and Triple-Negative Primary Breast Cancer in a BRCA1 Mutation Carrier |
| title_short | Synchronous Metastasizing High-Grade Papillary Serous Carcinoma of the Fallopian Tube and Triple-Negative Primary Breast Cancer in a BRCA1 Mutation Carrier |
| title_sort | synchronous metastasizing high grade papillary serous carcinoma of the fallopian tube and triple negative primary breast cancer in a brca1 mutation carrier |
| topic | fallopian tube carcinoma PARP inhibitors triple-negative invasive breast carcinoma high-grade papillary serous carcinoma brca1 germline mutation |
| url | https://www.mdpi.com/2392-7674/12/1/20 |
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