Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model
ABSTRACT Introduction Aurantio‐obtusin is a trihydroxyanthraquinone found in the seeds of Cassia tora and Cassia obtusifolia. Its neuroprotective, anti‐inflammatory, anti‐allergic, and antioxidant potential has been documented in multiple studies. While previous reports mention its potential as an a...
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Wiley
2025-03-01
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| Series: | Immunity, Inflammation and Disease |
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| Online Access: | https://doi.org/10.1002/iid3.70160 |
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| author | Mavis Sersah Nyarko Cynthia Amaning Danquah Aaron Opoku Antwi Benjamin Obukowho Emikpe Newman Osafo |
| author_facet | Mavis Sersah Nyarko Cynthia Amaning Danquah Aaron Opoku Antwi Benjamin Obukowho Emikpe Newman Osafo |
| author_sort | Mavis Sersah Nyarko |
| collection | DOAJ |
| description | ABSTRACT Introduction Aurantio‐obtusin is a trihydroxyanthraquinone found in the seeds of Cassia tora and Cassia obtusifolia. Its neuroprotective, anti‐inflammatory, anti‐allergic, and antioxidant potential has been documented in multiple studies. While previous reports mention its potential as an antiasthma agent, its effects on allergen‐induced airway inflammation have not been explored. Method Our study reports on the mechanisms by which aurantio‐obtusin exerts its effects on underlying inflammation in experimentally‐induced allergic asthma. The effect of aurantio‐obtusin pretreatment on molecular and histological changes in guinea pig lungs when challenged with aerosolized ovalbumin was assessed. Results Our results showed that aurantio‐obtusin significantly reduced ovalbumin (OVA)‐induced increase in serum OVA‐specific immunoglobulin E (OVA‐sIgE) and intercellular adhesion molecule (ICAM)‐1. Aurantio‐obtusin further suppressed inflammatory cytokine expression (IL‐8, TNF‐α, IL‐6 and thymic stromal lymphopoietin) as well as malondialdehyde, a product of oxidative stress in bronchial lavage. The histopathological assessment showed a reduced transit of inflammatory cells and reduced deposition of collagen in the lungs of aurantio‐obtusin‐treated guinea pigs. Conclusion Overall, the data suggests that aurantio‐obtusin mitigated ovalbumin‐induced airway inflammation by impeding the production of OVAsIgE and suppressing levels of key pro‐inflammatory cytokines. Our findings suggest that aurantio‐obtusin has potential benefits in the management of allergic airway inflammation in type 2 asthma. |
| format | Article |
| id | doaj-art-de10fa8f818a44abada1d3775fd50026 |
| institution | OA Journals |
| issn | 2050-4527 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Immunity, Inflammation and Disease |
| spelling | doaj-art-de10fa8f818a44abada1d3775fd500262025-08-20T01:49:47ZengWileyImmunity, Inflammation and Disease2050-45272025-03-01133n/an/a10.1002/iid3.70160Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma ModelMavis Sersah Nyarko0Cynthia Amaning Danquah1Aaron Opoku Antwi2Benjamin Obukowho Emikpe3Newman Osafo4Department of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology (KNUST) Kumasi GhanaDepartment of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology (KNUST) Kumasi GhanaDepartment of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology (KNUST) Kumasi GhanaDepartment of Pathobiology, School of Veterinary Medicine Kwame Nkrumah University of Science and Technology (KNUST) Kumasi GhanaDepartment of Pharmacology, Faculty of Pharmacy and Pharmaceutical Sciences Kwame Nkrumah University of Science and Technology (KNUST) Kumasi GhanaABSTRACT Introduction Aurantio‐obtusin is a trihydroxyanthraquinone found in the seeds of Cassia tora and Cassia obtusifolia. Its neuroprotective, anti‐inflammatory, anti‐allergic, and antioxidant potential has been documented in multiple studies. While previous reports mention its potential as an antiasthma agent, its effects on allergen‐induced airway inflammation have not been explored. Method Our study reports on the mechanisms by which aurantio‐obtusin exerts its effects on underlying inflammation in experimentally‐induced allergic asthma. The effect of aurantio‐obtusin pretreatment on molecular and histological changes in guinea pig lungs when challenged with aerosolized ovalbumin was assessed. Results Our results showed that aurantio‐obtusin significantly reduced ovalbumin (OVA)‐induced increase in serum OVA‐specific immunoglobulin E (OVA‐sIgE) and intercellular adhesion molecule (ICAM)‐1. Aurantio‐obtusin further suppressed inflammatory cytokine expression (IL‐8, TNF‐α, IL‐6 and thymic stromal lymphopoietin) as well as malondialdehyde, a product of oxidative stress in bronchial lavage. The histopathological assessment showed a reduced transit of inflammatory cells and reduced deposition of collagen in the lungs of aurantio‐obtusin‐treated guinea pigs. Conclusion Overall, the data suggests that aurantio‐obtusin mitigated ovalbumin‐induced airway inflammation by impeding the production of OVAsIgE and suppressing levels of key pro‐inflammatory cytokines. Our findings suggest that aurantio‐obtusin has potential benefits in the management of allergic airway inflammation in type 2 asthma.https://doi.org/10.1002/iid3.70160airway inflammationAllergyasthmaaurantio‐obtusinintercellular adhesion molecule‐1plant‐derived compound |
| spellingShingle | Mavis Sersah Nyarko Cynthia Amaning Danquah Aaron Opoku Antwi Benjamin Obukowho Emikpe Newman Osafo Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model Immunity, Inflammation and Disease airway inflammation Allergy asthma aurantio‐obtusin intercellular adhesion molecule‐1 plant‐derived compound |
| title | Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model |
| title_full | Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model |
| title_fullStr | Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model |
| title_full_unstemmed | Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model |
| title_short | Aurantio‐Obtusin Suppresses Airway Inflammation and Serum ICAM‐1 Expression in Guinea Pig Allergic Asthma Model |
| title_sort | aurantio obtusin suppresses airway inflammation and serum icam 1 expression in guinea pig allergic asthma model |
| topic | airway inflammation Allergy asthma aurantio‐obtusin intercellular adhesion molecule‐1 plant‐derived compound |
| url | https://doi.org/10.1002/iid3.70160 |
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