An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases
Mesenchymal stem or stromal cells (MSCs) are nonhematopoietic postnatal stem cells with self-renewal, multipotent differentiation, and potent immunomodulatory and anti-inflammatory capabilities, thus playing an important role in tissue repair and regeneration. Numerous clinical and preclinical studi...
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| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Stem Cells International |
| Online Access: | http://dx.doi.org/10.1155/2021/8834590 |
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| _version_ | 1832559726888484864 |
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| author | Yanyun Li Ziyu Ye Weiqin Yang Qunzhou Zhang Jincheng Zeng |
| author_facet | Yanyun Li Ziyu Ye Weiqin Yang Qunzhou Zhang Jincheng Zeng |
| author_sort | Yanyun Li |
| collection | DOAJ |
| description | Mesenchymal stem or stromal cells (MSCs) are nonhematopoietic postnatal stem cells with self-renewal, multipotent differentiation, and potent immunomodulatory and anti-inflammatory capabilities, thus playing an important role in tissue repair and regeneration. Numerous clinical and preclinical studies have demonstrated the potential application of MSCs in the treatment of tissue inflammation and immune diseases, including inflammatory skin diseases. Therefore, understanding the biological and immunological characteristics of MSCs is important to standardize and optimize MSC-based regenerative therapy. In this review, we highlight the mechanisms underlying MSC-mediated immunomodulation and tissue repair/regeneration and present the latest development of MSC-based clinical trials on cutaneous diseases. |
| format | Article |
| id | doaj-art-de0f1cabda99483db08139554dfbac41 |
| institution | Kabale University |
| issn | 1687-966X 1687-9678 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stem Cells International |
| spelling | doaj-art-de0f1cabda99483db08139554dfbac412025-02-03T01:29:23ZengWileyStem Cells International1687-966X1687-96782021-01-01202110.1155/2021/88345908834590An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous DiseasesYanyun Li0Ziyu Ye1Weiqin Yang2Qunzhou Zhang3Jincheng Zeng4Guangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Medical University, Dongguan 523808, ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Medical University, Dongguan 523808, ChinaGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Medical University, Dongguan 523808, ChinaDepartment of Oral and Maxillofacial Surgery and Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia 19104, USAGuangdong Provincial Key Laboratory of Medical Molecular Diagnostics, Dongguan Key Laboratory of Medical Bioactive Molecular Developmental and Translational Research, Guangdong Medical University, Dongguan 523808, ChinaMesenchymal stem or stromal cells (MSCs) are nonhematopoietic postnatal stem cells with self-renewal, multipotent differentiation, and potent immunomodulatory and anti-inflammatory capabilities, thus playing an important role in tissue repair and regeneration. Numerous clinical and preclinical studies have demonstrated the potential application of MSCs in the treatment of tissue inflammation and immune diseases, including inflammatory skin diseases. Therefore, understanding the biological and immunological characteristics of MSCs is important to standardize and optimize MSC-based regenerative therapy. In this review, we highlight the mechanisms underlying MSC-mediated immunomodulation and tissue repair/regeneration and present the latest development of MSC-based clinical trials on cutaneous diseases.http://dx.doi.org/10.1155/2021/8834590 |
| spellingShingle | Yanyun Li Ziyu Ye Weiqin Yang Qunzhou Zhang Jincheng Zeng An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases Stem Cells International |
| title | An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases |
| title_full | An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases |
| title_fullStr | An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases |
| title_full_unstemmed | An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases |
| title_short | An Update on the Potential of Mesenchymal Stem Cell Therapy for Cutaneous Diseases |
| title_sort | update on the potential of mesenchymal stem cell therapy for cutaneous diseases |
| url | http://dx.doi.org/10.1155/2021/8834590 |
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