Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes
Objectives: Graft material can impact fusion rates in anterior lumbar interbody fusion (ALIF) procedures. We aimed to evaluate the clinical and radiographic outcomes of patients who underwent ALIF with a novel osteoinductive demineralised bone allograft (DBA) due to the paucity of peer reviewed lite...
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Elsevier
2025-04-01
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| Series: | World Neurosurgery: X |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590139725000146 |
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| author | Charlie R. Faulks Dean T. Biddau Michael D. Selby Ralph J. Mobbs Gregory M. Malham |
| author_facet | Charlie R. Faulks Dean T. Biddau Michael D. Selby Ralph J. Mobbs Gregory M. Malham |
| author_sort | Charlie R. Faulks |
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| description | Objectives: Graft material can impact fusion rates in anterior lumbar interbody fusion (ALIF) procedures. We aimed to evaluate the clinical and radiographic outcomes of patients who underwent ALIF with a novel osteoinductive demineralised bone allograft (DBA) due to the paucity of peer reviewed literature. Methods: Includes 112 consecutive patients from 3 senior spine surgeons (multi-centre) undergoing stand-alone ALIF with osteoinductive DBA (Allovance® Crunch Plus) between January 1, 2019 and January 1, 2022. Patient reported outcome measures included visual analog scale (VAS) back pain, Oswestry disability index (ODI) and 12-Item Short Form Survey (SF-12) measured at preoperative, 6-week, 6-month, 12-month, and 24-month time points. CT imaging conducted postoperative day-2 for instrumentation positioning then at either 6-, 12- or 24-months for interbody fusion status. If fusion was achieved no further CTs were undertaken. Minimum follow-up was 12 months (12–24). Results: Mean age of cohort (51.8 % male) was 51.4 ± 14.1 years. Procedures consisted of; single level (n = 71), double level (n = 20), or quadruple level (n = 2) ALIF, and hybrid procedures (n = 19, disc replacement superior to ALIF). Preoperative mean VAS back (7.5 ± 1.5), and ODI (30.4 ± 7.8) significantly (p < 0.0001) decreased (2.5 ± 2.1, 12.2 ± 8.1); SF-12 physical (29.4 ± 5.7), and SF-12 mental (41.3 ± 12.2) showed improvements (p < 0.05) at 12-months follow-up (47.5 ± 8.8, 52.6 ± 7.6). Fusion was achieved at 6-months in 23.6 %, 12-months in 86.8 %, and 24-months in 93.4 % of patients. Nineteen (30.6 %) patients suffered acute (n = 8) and chronic (>6 months, n = 11) complications. Conclusions: Patients undergoing ALIF with this novel osteoinductive DBA demonstrated significant improvement in pain, disability and function with high fusion rates over 24-month follow-up. |
| format | Article |
| id | doaj-art-de0c5d78d3a246a19c654c7f3e93467c |
| institution | OA Journals |
| issn | 2590-1397 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
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| series | World Neurosurgery: X |
| spelling | doaj-art-de0c5d78d3a246a19c654c7f3e93467c2025-08-20T01:55:38ZengElsevierWorld Neurosurgery: X2590-13972025-04-012610044010.1016/j.wnsx.2025.100440Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomesCharlie R. Faulks0Dean T. Biddau1Michael D. Selby2Ralph J. Mobbs3Gregory M. Malham4Neuroscience Institute, Epworth HealthCare, Melbourne, VIC, AustraliaNeuroscience Institute, Epworth HealthCare, Melbourne, VIC, Australia; School of Biomedical Science, Queensland University of Technology, Brisbane, QLD, AustraliaDiscipline of Orthopaedics and Trauma, The University of Adelaide, Adelaide, SA, Australia; Adelaide Spine and Brain, Adelaide Spine Clinic, Adelaide, SA, AustraliaNeuroSpine Surgery Research Group (NSURG), Randwick, NSW, Australia; NeuroSpine Clinic, Prince of Wales Private Hospital, Randwick, NSW, Australia; Faculty of Medicine, University of New South Wales (UNSW), Randwick, NSW, AustraliaNeuroscience Institute, Epworth HealthCare, Melbourne, VIC, Australia; Department of Surgery, University of Melbourne, Parkville, VIC, Australia; Swinburne University of Technology, Melbourne, VIC, Australia; Corresponding author. Epworth HealthCare, 89 Bridge Road, Suite 8.3, Danks Tower, Richmond, Melbourne, VIC, 3121, Australia.Objectives: Graft material can impact fusion rates in anterior lumbar interbody fusion (ALIF) procedures. We aimed to evaluate the clinical and radiographic outcomes of patients who underwent ALIF with a novel osteoinductive demineralised bone allograft (DBA) due to the paucity of peer reviewed literature. Methods: Includes 112 consecutive patients from 3 senior spine surgeons (multi-centre) undergoing stand-alone ALIF with osteoinductive DBA (Allovance® Crunch Plus) between January 1, 2019 and January 1, 2022. Patient reported outcome measures included visual analog scale (VAS) back pain, Oswestry disability index (ODI) and 12-Item Short Form Survey (SF-12) measured at preoperative, 6-week, 6-month, 12-month, and 24-month time points. CT imaging conducted postoperative day-2 for instrumentation positioning then at either 6-, 12- or 24-months for interbody fusion status. If fusion was achieved no further CTs were undertaken. Minimum follow-up was 12 months (12–24). Results: Mean age of cohort (51.8 % male) was 51.4 ± 14.1 years. Procedures consisted of; single level (n = 71), double level (n = 20), or quadruple level (n = 2) ALIF, and hybrid procedures (n = 19, disc replacement superior to ALIF). Preoperative mean VAS back (7.5 ± 1.5), and ODI (30.4 ± 7.8) significantly (p < 0.0001) decreased (2.5 ± 2.1, 12.2 ± 8.1); SF-12 physical (29.4 ± 5.7), and SF-12 mental (41.3 ± 12.2) showed improvements (p < 0.05) at 12-months follow-up (47.5 ± 8.8, 52.6 ± 7.6). Fusion was achieved at 6-months in 23.6 %, 12-months in 86.8 %, and 24-months in 93.4 % of patients. Nineteen (30.6 %) patients suffered acute (n = 8) and chronic (>6 months, n = 11) complications. Conclusions: Patients undergoing ALIF with this novel osteoinductive DBA demonstrated significant improvement in pain, disability and function with high fusion rates over 24-month follow-up.http://www.sciencedirect.com/science/article/pii/S2590139725000146AllograftAnterior lumbar interbody fusionComputed tomographyOsteoinductive allograftDemineralised bone allograftPatient reported outcome measures |
| spellingShingle | Charlie R. Faulks Dean T. Biddau Michael D. Selby Ralph J. Mobbs Gregory M. Malham Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes World Neurosurgery: X Allograft Anterior lumbar interbody fusion Computed tomography Osteoinductive allograft Demineralised bone allograft Patient reported outcome measures |
| title | Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes |
| title_full | Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes |
| title_fullStr | Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes |
| title_full_unstemmed | Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes |
| title_short | Anterior lumbar interbody fusion with a novel osteoinductive allograft – Mid-term clinical and radiographic outcomes |
| title_sort | anterior lumbar interbody fusion with a novel osteoinductive allograft mid term clinical and radiographic outcomes |
| topic | Allograft Anterior lumbar interbody fusion Computed tomography Osteoinductive allograft Demineralised bone allograft Patient reported outcome measures |
| url | http://www.sciencedirect.com/science/article/pii/S2590139725000146 |
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