Environmental occurrence of antibiotic resistance, control measures and challenges in finding therapeutic management
Antimicrobial resistance represents a growing threat to public health, with the World Health Organization placing it among the top ten global health threats. Inappropriate use of antibiotics in healthcare and agriculture contributes to their dispersal into the environment, thereby accelerating bacte...
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KeAi Communications Co., Ltd.
2025-03-01
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| Series: | Emerging Contaminants |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405665024001410 |
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| author | Rajendra Singh Keugtae Kim |
| author_facet | Rajendra Singh Keugtae Kim |
| author_sort | Rajendra Singh |
| collection | DOAJ |
| description | Antimicrobial resistance represents a growing threat to public health, with the World Health Organization placing it among the top ten global health threats. Inappropriate use of antibiotics in healthcare and agriculture contributes to their dispersal into the environment, thereby accelerating bacterial resistance through the transfer of genetic elements and antibiotic resistance genes. The widespread prevalence of antibiotic-resistance genes and bacteria has been confirmed in both soil and water across various climates. Additionally, the detection of these resistant genes and bacteria in polar regions is particularly alarming due to their potential to spread and persist in pristine environments. The impact of antibiotic resistance is considerable, and addressing the associated challenges necessitates a collaborative effort involving healthcare professionals, government entities, scientists, and the general public. Most of the recent scholarly reviews regarding antibiotic resistance predominantly concentrate on either the overarching concept of antimicrobial resistance or they delve into particular sources, pathways, or environmental ramifications. In contrast, this extensive state-of-the-art review aspires to furnish an updated synthesis of the distribution of antibiotic resistance, its repercussions on human health and economy, as well as innovative therapeutic strategies that exhibit potential in combating antibiotic-resistant bacteria. Furthermore, it scrutinizes the challenges that impede the progression of novel therapeutic modalities and the implementation of effective control strategies. The investigation provides a comprehensive overview of the classifications of antibiotic resistance genes, systematically organized by antibiotic categories. Additionally, it underscores global management strategies, particularly through stewardship programs, promising combination therapies aimed at augmenting drug efficacy, and alternative methodologies to antibiotics for the treatment of bacterial infections. |
| format | Article |
| id | doaj-art-de0ac6c7d84741289643a84fe3bb7465 |
| institution | OA Journals |
| issn | 2405-6650 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Emerging Contaminants |
| spelling | doaj-art-de0ac6c7d84741289643a84fe3bb74652025-08-20T02:17:29ZengKeAi Communications Co., Ltd.Emerging Contaminants2405-66502025-03-0111110044010.1016/j.emcon.2024.100440Environmental occurrence of antibiotic resistance, control measures and challenges in finding therapeutic managementRajendra Singh0Keugtae Kim1Department of Biological and Environmental Science, Dongguk University, Goyang, Gyeonggi-do, South KoreaCorresponding author.; Department of Biological and Environmental Science, Dongguk University, Goyang, Gyeonggi-do, South KoreaAntimicrobial resistance represents a growing threat to public health, with the World Health Organization placing it among the top ten global health threats. Inappropriate use of antibiotics in healthcare and agriculture contributes to their dispersal into the environment, thereby accelerating bacterial resistance through the transfer of genetic elements and antibiotic resistance genes. The widespread prevalence of antibiotic-resistance genes and bacteria has been confirmed in both soil and water across various climates. Additionally, the detection of these resistant genes and bacteria in polar regions is particularly alarming due to their potential to spread and persist in pristine environments. The impact of antibiotic resistance is considerable, and addressing the associated challenges necessitates a collaborative effort involving healthcare professionals, government entities, scientists, and the general public. Most of the recent scholarly reviews regarding antibiotic resistance predominantly concentrate on either the overarching concept of antimicrobial resistance or they delve into particular sources, pathways, or environmental ramifications. In contrast, this extensive state-of-the-art review aspires to furnish an updated synthesis of the distribution of antibiotic resistance, its repercussions on human health and economy, as well as innovative therapeutic strategies that exhibit potential in combating antibiotic-resistant bacteria. Furthermore, it scrutinizes the challenges that impede the progression of novel therapeutic modalities and the implementation of effective control strategies. The investigation provides a comprehensive overview of the classifications of antibiotic resistance genes, systematically organized by antibiotic categories. Additionally, it underscores global management strategies, particularly through stewardship programs, promising combination therapies aimed at augmenting drug efficacy, and alternative methodologies to antibiotics for the treatment of bacterial infections.http://www.sciencedirect.com/science/article/pii/S2405665024001410Antibiotic resistanceAntibiotic resistance genesHealthcareGlobal healthPublic health |
| spellingShingle | Rajendra Singh Keugtae Kim Environmental occurrence of antibiotic resistance, control measures and challenges in finding therapeutic management Emerging Contaminants Antibiotic resistance Antibiotic resistance genes Healthcare Global health Public health |
| title | Environmental occurrence of antibiotic resistance, control measures and challenges in finding therapeutic management |
| title_full | Environmental occurrence of antibiotic resistance, control measures and challenges in finding therapeutic management |
| title_fullStr | Environmental occurrence of antibiotic resistance, control measures and challenges in finding therapeutic management |
| title_full_unstemmed | Environmental occurrence of antibiotic resistance, control measures and challenges in finding therapeutic management |
| title_short | Environmental occurrence of antibiotic resistance, control measures and challenges in finding therapeutic management |
| title_sort | environmental occurrence of antibiotic resistance control measures and challenges in finding therapeutic management |
| topic | Antibiotic resistance Antibiotic resistance genes Healthcare Global health Public health |
| url | http://www.sciencedirect.com/science/article/pii/S2405665024001410 |
| work_keys_str_mv | AT rajendrasingh environmentaloccurrenceofantibioticresistancecontrolmeasuresandchallengesinfindingtherapeuticmanagement AT keugtaekim environmentaloccurrenceofantibioticresistancecontrolmeasuresandchallengesinfindingtherapeuticmanagement |