Inhibition of NRF1/ABCC1 improves chemosensitivity of human lung adenocarcinoma cell lines to cisplatin

Inhibition of NRF1/ABCC1 improves chemosensitivity of human lung adenocarcinoma cell lines to cisplatin

Objective To explore the effect of nuclear respiratory factor 1(NRF1) activation of ATP binding cassette transporter C1(ABCC1) transcription on cisplatin resistance in lung adenocarcinoma cells and its potential mechanisms. Methods The expression levels of ABCC1 in lung adenocarcinoma tumor tissue...

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Bibliographic Details
Main Author: CHEN Qingxia, LIANG Yuling, LUO Yalan, NIU Bin
Format: Article
Language:zho
Published: Institute of Basic Medical Sciences and Peking Union Medical College Hospital, Chinese Academy of Medical Sciences / Peking Union Medical College. 2025-01-01
Series:Jichu yixue yu linchuang
Subjects:
nuclear respiratory factor 1(nrf1)|atp binding cassette transporter c1(abcc1)|lung adenocarcinoma|epithelial-mesenchymal transition|chemotherapy resistance
Online Access:https://journal11.magtechjournal.com/Jwk_jcyxylc/fileup/1001-6325/PDF/1001-6325-2025-45-1-51.pdf
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