Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation

Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation

Hypoxia is a characteristic feature of the tumor microenvironment that significantly influences cancer progression and treatment responses. Hypoxia-inducible factor (HIF), a key regulator of hypoxic adaptation, has been demonstrated to modulate hypoxic gene expression profiles and signaling networks...

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Bibliographic Details
Main Authors: Lifeng Gan, Peiyue Luo, Junrong Zou, Wei Li, Qi Chen, Le Cheng, Fangtao Zhang, Haidong Zhong, Yiran Lu, Liying Zheng, Biao Qian
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-08-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
hypoxia
HIF
lncRNA
digestive system tumors
liver cancer
colorectal cancer
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2025.1611889/full
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