Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation
Hypoxia is a characteristic feature of the tumor microenvironment that significantly influences cancer progression and treatment responses. Hypoxia-inducible factor (HIF), a key regulator of hypoxic adaptation, has been demonstrated to modulate hypoxic gene expression profiles and signaling networks...
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cell and Developmental Biology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcell.2025.1611889/full |
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| author | Lifeng Gan Lifeng Gan Lifeng Gan Peiyue Luo Peiyue Luo Peiyue Luo Junrong Zou Junrong Zou Wei Li Wei Li Wei Li Qi Chen Qi Chen Qi Chen Le Cheng Le Cheng Le Cheng Fangtao Zhang Fangtao Zhang Fangtao Zhang Haidong Zhong Haidong Zhong Haidong Zhong Yiran Lu Liying Zheng Biao Qian Biao Qian |
| author_facet | Lifeng Gan Lifeng Gan Lifeng Gan Peiyue Luo Peiyue Luo Peiyue Luo Junrong Zou Junrong Zou Wei Li Wei Li Wei Li Qi Chen Qi Chen Qi Chen Le Cheng Le Cheng Le Cheng Fangtao Zhang Fangtao Zhang Fangtao Zhang Haidong Zhong Haidong Zhong Haidong Zhong Yiran Lu Liying Zheng Biao Qian Biao Qian |
| author_sort | Lifeng Gan |
| collection | DOAJ |
| description | Hypoxia is a characteristic feature of the tumor microenvironment that significantly influences cancer progression and treatment responses. Hypoxia-inducible factor (HIF), a key regulator of hypoxic adaptation, has been demonstrated to modulate hypoxic gene expression profiles and signaling networks, thereby serving as a potential therapeutic target. Long-stranded non-coding RNAs (lncRNAs), defined as non-coding RNAs exceeding 200 nucleotides in length, regulate various cellular processes by modulating gene expression at transcriptional, post-transcriptional, and epigenetic levels. Evidence suggests that lncRNAs can be regulated by HIF at the transcriptional level. Conversely, HIF itself can be modulated by numerous lncRNAs, with alterations in these lncRNAs being associated with tumorigenesis, resulting in a reciprocal regulatory network. Recently, the critical role of lncRNAs in hypoxia-driven cancer progression has been elucidated in digestive tumors, including colorectal, pancreatic, gastric, and hepatocellular carcinomas. An increasing number of studies have revealed the complex interplay between lncRNAs and HIF in regulating various processes such as proliferation, metastasis, apoptosis, and drug resistance. In this paper, we aim to provide a comprehensive summary of recent advances regarding the roles of hypoxia and lncRNAs in digestive system tumors and to illustrate the mechanisms through which lncRNAs interact with hypoxia in tumor cells. This will enhance our understanding of the regulatory roles of lncRNAs in modulating the microenvironment of digestive system tumors, thereby facilitating the development of novel anticancer drugs. |
| format | Article |
| id | doaj-art-ddf8167610fe4c4f8d62453ef0ce6374 |
| institution | Kabale University |
| issn | 2296-634X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cell and Developmental Biology |
| spelling | doaj-art-ddf8167610fe4c4f8d62453ef0ce63742025-08-20T03:40:50ZengFrontiers Media S.A.Frontiers in Cell and Developmental Biology2296-634X2025-08-011310.3389/fcell.2025.16118891611889Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translationLifeng Gan0Lifeng Gan1Lifeng Gan2Peiyue Luo3Peiyue Luo4Peiyue Luo5Junrong Zou6Junrong Zou7Wei Li8Wei Li9Wei Li10Qi Chen11Qi Chen12Qi Chen13Le Cheng14Le Cheng15Le Cheng16Fangtao Zhang17Fangtao Zhang18Fangtao Zhang19Haidong Zhong20Haidong Zhong21Haidong Zhong22Yiran Lu23Liying Zheng24Biao Qian25Biao Qian26The First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology and Andrology, The Key Laboratory of the First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology and Andrology, The Key Laboratory of the First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology and Andrology, The Key Laboratory of the First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology and Andrology, The Key Laboratory of the First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology and Andrology, The Key Laboratory of the First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology and Andrology, The Key Laboratory of the First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology and Andrology, The Key Laboratory of the First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology and Andrology, The Key Laboratory of the First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, ChinaThe First Clinical College, Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Graduate, The First Affiliated Hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology, The First Affiliated hospital of Gannan Medical University, Ganzhou, Jiangxi, ChinaDepartment of Urology and Andrology, The Key Laboratory of the First Clinical Medical College of Gannan Medical University, Ganzhou, Jiangxi, ChinaHypoxia is a characteristic feature of the tumor microenvironment that significantly influences cancer progression and treatment responses. Hypoxia-inducible factor (HIF), a key regulator of hypoxic adaptation, has been demonstrated to modulate hypoxic gene expression profiles and signaling networks, thereby serving as a potential therapeutic target. Long-stranded non-coding RNAs (lncRNAs), defined as non-coding RNAs exceeding 200 nucleotides in length, regulate various cellular processes by modulating gene expression at transcriptional, post-transcriptional, and epigenetic levels. Evidence suggests that lncRNAs can be regulated by HIF at the transcriptional level. Conversely, HIF itself can be modulated by numerous lncRNAs, with alterations in these lncRNAs being associated with tumorigenesis, resulting in a reciprocal regulatory network. Recently, the critical role of lncRNAs in hypoxia-driven cancer progression has been elucidated in digestive tumors, including colorectal, pancreatic, gastric, and hepatocellular carcinomas. An increasing number of studies have revealed the complex interplay between lncRNAs and HIF in regulating various processes such as proliferation, metastasis, apoptosis, and drug resistance. In this paper, we aim to provide a comprehensive summary of recent advances regarding the roles of hypoxia and lncRNAs in digestive system tumors and to illustrate the mechanisms through which lncRNAs interact with hypoxia in tumor cells. This will enhance our understanding of the regulatory roles of lncRNAs in modulating the microenvironment of digestive system tumors, thereby facilitating the development of novel anticancer drugs.https://www.frontiersin.org/articles/10.3389/fcell.2025.1611889/fullhypoxiaHIFlncRNAdigestive system tumorsliver cancercolorectal cancer |
| spellingShingle | Lifeng Gan Lifeng Gan Lifeng Gan Peiyue Luo Peiyue Luo Peiyue Luo Junrong Zou Junrong Zou Wei Li Wei Li Wei Li Qi Chen Qi Chen Qi Chen Le Cheng Le Cheng Le Cheng Fangtao Zhang Fangtao Zhang Fangtao Zhang Haidong Zhong Haidong Zhong Haidong Zhong Yiran Lu Liying Zheng Biao Qian Biao Qian Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation Frontiers in Cell and Developmental Biology hypoxia HIF lncRNA digestive system tumors liver cancer colorectal cancer |
| title | Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation |
| title_full | Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation |
| title_fullStr | Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation |
| title_full_unstemmed | Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation |
| title_short | Crosstalk between hypoxia-inducible factor (HIF) and lncRNAs in digestive tumors: from molecular mechanisms to clinical translation |
| title_sort | crosstalk between hypoxia inducible factor hif and lncrnas in digestive tumors from molecular mechanisms to clinical translation |
| topic | hypoxia HIF lncRNA digestive system tumors liver cancer colorectal cancer |
| url | https://www.frontiersin.org/articles/10.3389/fcell.2025.1611889/full |
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