Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease Specialists for the Diagnosis and Treatment of Chronic Hepatitis C
Аim: diagnosis and treatment algorithms in the clinical recommendations intended for general practitioners, gastroenterologists, infectious disease specialists, hepatologists on the of chronic hepatitis C are presented.Summary. Chronic viral hepatitis C is a socially significant infection, the incid...
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2023-06-01
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| Series: | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
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| Online Access: | https://www.gastro-j.ru/jour/article/view/807 |
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| author | V. T. Ivashkin V. P. Chulanov N. A. Mamonova M. V. Maevskaya M. S. Zharkova I. N. Tikhonov P. O. Bogomolov E. V. Volchkova A. S. Dmitriev O. O. Znojko E. A. Klimova K. V. Kozlov I. E. Kravchenko E. Yu. Malinnikova R. V. Maslennikov M. I. Mikhailov K. E. Novak I. G. Nikitin V. E. Syutkin E. V. Esaulenko A. A. Sheptulin E. N. Shirokova N. D. Yushchuk |
| author_facet | V. T. Ivashkin V. P. Chulanov N. A. Mamonova M. V. Maevskaya M. S. Zharkova I. N. Tikhonov P. O. Bogomolov E. V. Volchkova A. S. Dmitriev O. O. Znojko E. A. Klimova K. V. Kozlov I. E. Kravchenko E. Yu. Malinnikova R. V. Maslennikov M. I. Mikhailov K. E. Novak I. G. Nikitin V. E. Syutkin E. V. Esaulenko A. A. Sheptulin E. N. Shirokova N. D. Yushchuk |
| author_sort | V. T. Ivashkin |
| collection | DOAJ |
| description | Аim: diagnosis and treatment algorithms in the clinical recommendations intended for general practitioners, gastroenterologists, infectious disease specialists, hepatologists on the of chronic hepatitis C are presented.Summary. Chronic viral hepatitis C is a socially significant infection, the incidence of which in the Russian Federation remains significantly high. Over the past 10 years, great progress has been made in the treatment of hepatitis C — direct acting antiviral drugs have appeared. The spectrum of their effectiveness allows to achieve a sustained virological response in more than 90 % of cases, even in groups that were not previously considered even as candidates for therapy or were difficult to treat — patients receiving renal replacement therapy, after liver transplantation (or other organs), at the stage of decompensated liver cirrhosis, HIV co-infected, etc. Interferons are excluded from the recommendations due to their low effectiveness and a wide range of adverse events. The indications for the treatment have been expanded, namely, the fact of confirmation of viral replication. The terms of dispensary observation of patients without cirrhosis of the liver have been reduced (up to 12 weeks after the end of therapy). Also, these recommendations present approaches to active screening of hepatitis in risk groups, preventive and rehabilitation measures after the end of treatment.Conclusion. Great success has been achieved in the treatment of chronic hepatitis C. In most cases, eradication of viral HCV infection is a real task even in patients at the stage of cirrhosis of the liver, with impaired renal function, HIV co-infection, after solid organs transplantation. |
| format | Article |
| id | doaj-art-ddf0b4b1638842fa940763cca94357ee |
| institution | Kabale University |
| issn | 1382-4376 2658-6673 |
| language | Russian |
| publishDate | 2023-06-01 |
| publisher | Gastro LLC |
| record_format | Article |
| series | Российский журнал гастроэнтерологии, гепатологии, колопроктологии |
| spelling | doaj-art-ddf0b4b1638842fa940763cca94357ee2025-02-10T16:14:38ZrusGastro LLCРоссийский журнал гастроэнтерологии, гепатологии, колопроктологии1382-43762658-66732023-06-013318412410.22416/1382-4376-2023-33-1-84-124536Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease Specialists for the Diagnosis and Treatment of Chronic Hepatitis CV. T. Ivashkin0V. P. Chulanov1N. A. Mamonova2M. V. Maevskaya3M. S. Zharkova4I. N. Tikhonov5P. O. Bogomolov6E. V. Volchkova7A. S. Dmitriev8O. O. Znojko9E. A. Klimova10K. V. Kozlov11I. E. Kravchenko12E. Yu. Malinnikova13R. V. Maslennikov14M. I. Mikhailov15K. E. Novak16I. G. Nikitin17V. E. Syutkin18E. V. Esaulenko19A. A. Sheptulin20E. N. Shirokova21N. D. Yushchuk22Sechenov First Moscow State Medical University (Sechenov University)Center for Epidemiologically Significant Infectious Diseases, National Medical Research Center for Phthisiopulmonology and Infectious DiseasesCenter for Epidemiologically Significant Infectious Diseases, National Medical Research Center for Phthisiopulmonology and Infectious DiseasesSechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)M.F. Vladimirsky Moscow Regional Research Clinical InstituteSechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Moscow State University of Medicine and DentistryMoscow State University of Medicine and DentistryKirov Military Medical AcademyKazan State Medical UniversityDepartment of Virology, Russian Medical Academy of Continuing Professional EducationSechenov First Moscow State Medical University (Sechenov University)North-Western State Medical University named after I.I. MechnikovSaint-Petersburg State UniversityPirogov Russian National Research UniversitySklifosovsky Clinical and Research Institute for Emergency Medicine; Russian State Research Center — Burnazyan Federal Medical Biophysical CenterSaint-Petersburg State UniversitySechenov First Moscow State Medical University (Sechenov University)Sechenov First Moscow State Medical University (Sechenov University)Moscow State University of Medicine and DentistryАim: diagnosis and treatment algorithms in the clinical recommendations intended for general practitioners, gastroenterologists, infectious disease specialists, hepatologists on the of chronic hepatitis C are presented.Summary. Chronic viral hepatitis C is a socially significant infection, the incidence of which in the Russian Federation remains significantly high. Over the past 10 years, great progress has been made in the treatment of hepatitis C — direct acting antiviral drugs have appeared. The spectrum of their effectiveness allows to achieve a sustained virological response in more than 90 % of cases, even in groups that were not previously considered even as candidates for therapy or were difficult to treat — patients receiving renal replacement therapy, after liver transplantation (or other organs), at the stage of decompensated liver cirrhosis, HIV co-infected, etc. Interferons are excluded from the recommendations due to their low effectiveness and a wide range of adverse events. The indications for the treatment have been expanded, namely, the fact of confirmation of viral replication. The terms of dispensary observation of patients without cirrhosis of the liver have been reduced (up to 12 weeks after the end of therapy). Also, these recommendations present approaches to active screening of hepatitis in risk groups, preventive and rehabilitation measures after the end of treatment.Conclusion. Great success has been achieved in the treatment of chronic hepatitis C. In most cases, eradication of viral HCV infection is a real task even in patients at the stage of cirrhosis of the liver, with impaired renal function, HIV co-infection, after solid organs transplantation.https://www.gastro-j.ru/jour/article/view/807hepatitis cvirushcv infectionliver cirrhosisliver transplantationco-infectionliver cancerdrugs with direct antiviral actionribavirin |
| spellingShingle | V. T. Ivashkin V. P. Chulanov N. A. Mamonova M. V. Maevskaya M. S. Zharkova I. N. Tikhonov P. O. Bogomolov E. V. Volchkova A. S. Dmitriev O. O. Znojko E. A. Klimova K. V. Kozlov I. E. Kravchenko E. Yu. Malinnikova R. V. Maslennikov M. I. Mikhailov K. E. Novak I. G. Nikitin V. E. Syutkin E. V. Esaulenko A. A. Sheptulin E. N. Shirokova N. D. Yushchuk Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease Specialists for the Diagnosis and Treatment of Chronic Hepatitis C Российский журнал гастроэнтерологии, гепатологии, колопроктологии hepatitis c virus hcv infection liver cirrhosis liver transplantation co-infection liver cancer drugs with direct antiviral action ribavirin |
| title | Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease Specialists for the Diagnosis and Treatment of Chronic Hepatitis C |
| title_full | Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease Specialists for the Diagnosis and Treatment of Chronic Hepatitis C |
| title_fullStr | Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease Specialists for the Diagnosis and Treatment of Chronic Hepatitis C |
| title_full_unstemmed | Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease Specialists for the Diagnosis and Treatment of Chronic Hepatitis C |
| title_short | Clinical Practice Guidelines of the Russian Society for the Study of the Liver, the Russian Gastroenterological Association, the National Scientific Society of Infectious Disease Specialists for the Diagnosis and Treatment of Chronic Hepatitis C |
| title_sort | clinical practice guidelines of the russian society for the study of the liver the russian gastroenterological association the national scientific society of infectious disease specialists for the diagnosis and treatment of chronic hepatitis c |
| topic | hepatitis c virus hcv infection liver cirrhosis liver transplantation co-infection liver cancer drugs with direct antiviral action ribavirin |
| url | https://www.gastro-j.ru/jour/article/view/807 |
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