The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells
Physical exercise accelerates the mobilization of free fatty acids from white adipocytes to provide fuel for energy. This happens in several tissues and helps to regulate a whole-body state of metabolism. Under these conditions, the hydrolysis of triacylglycerol (TG) that is found in white adipocyte...
Saved in:
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2015-01-01
|
| Series: | Journal of Obesity |
| Online Access: | http://dx.doi.org/10.1155/2015/473430 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832562226238586880 |
|---|---|
| author | Junetsu Ogasawara Tetsuya Izawa Tomonobu Sakurai Takuya Sakurai Ken Shirato Yoshinaga Ishibashi Hitoshi Ishida Hideki Ohno Takako Kizaki |
| author_facet | Junetsu Ogasawara Tetsuya Izawa Tomonobu Sakurai Takuya Sakurai Ken Shirato Yoshinaga Ishibashi Hitoshi Ishida Hideki Ohno Takako Kizaki |
| author_sort | Junetsu Ogasawara |
| collection | DOAJ |
| description | Physical exercise accelerates the mobilization of free fatty acids from white adipocytes to provide fuel for energy. This happens in several tissues and helps to regulate a whole-body state of metabolism. Under these conditions, the hydrolysis of triacylglycerol (TG) that is found in white adipocytes is known to be augmented via the activation of these lipolytic events, which is referred to as the “lipolytic cascade.” Indeed, evidence has shown that the lipolytic responses in white adipocytes are upregulated by continuous exercise training (ET) through the adaptive changes in molecules that constitute the lipolytic cascade. During the past few decades, many lipolysis-related molecules have been identified. Of note, the discovery of a new lipase, known as adipose triglyceride lipase, has redefined the existing concepts of the hormone-sensitive lipase-dependent hydrolysis of TG in white adipocytes. This review outlines the alterations in the lipolytic molecules of white adipocytes that result from ET, which includes the molecular regulation of TG lipases through the lipolytic cascade. |
| format | Article |
| id | doaj-art-ddf04844ea7d4537a3c07bd77a1ead19 |
| institution | Kabale University |
| issn | 2090-0708 2090-0716 |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Obesity |
| spelling | doaj-art-ddf04844ea7d4537a3c07bd77a1ead192025-02-03T01:23:08ZengWileyJournal of Obesity2090-07082090-07162015-01-01201510.1155/2015/473430473430The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose CellsJunetsu Ogasawara0Tetsuya Izawa1Tomonobu Sakurai2Takuya Sakurai3Ken Shirato4Yoshinaga Ishibashi5Hitoshi Ishida6Hideki Ohno7Takako Kizaki8Department of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, JapanGraduate School of Health and Sports Science, Doshisha University, Kyotanabe, Kyoto 610-0394, JapanFaculty of Culture and Sport Policy, Toin University of Yokohama, Yokohama, Kanagawa 225-8503, JapanDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, JapanDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, JapanDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, JapanDepartment of Third Internal Medicine, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, JapanDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, JapanDepartment of Molecular Predictive Medicine and Sport Science, Kyorin University, School of Medicine, Mitaka, Tokyo 181-8611, JapanPhysical exercise accelerates the mobilization of free fatty acids from white adipocytes to provide fuel for energy. This happens in several tissues and helps to regulate a whole-body state of metabolism. Under these conditions, the hydrolysis of triacylglycerol (TG) that is found in white adipocytes is known to be augmented via the activation of these lipolytic events, which is referred to as the “lipolytic cascade.” Indeed, evidence has shown that the lipolytic responses in white adipocytes are upregulated by continuous exercise training (ET) through the adaptive changes in molecules that constitute the lipolytic cascade. During the past few decades, many lipolysis-related molecules have been identified. Of note, the discovery of a new lipase, known as adipose triglyceride lipase, has redefined the existing concepts of the hormone-sensitive lipase-dependent hydrolysis of TG in white adipocytes. This review outlines the alterations in the lipolytic molecules of white adipocytes that result from ET, which includes the molecular regulation of TG lipases through the lipolytic cascade.http://dx.doi.org/10.1155/2015/473430 |
| spellingShingle | Junetsu Ogasawara Tetsuya Izawa Tomonobu Sakurai Takuya Sakurai Ken Shirato Yoshinaga Ishibashi Hitoshi Ishida Hideki Ohno Takako Kizaki The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells Journal of Obesity |
| title | The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells |
| title_full | The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells |
| title_fullStr | The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells |
| title_full_unstemmed | The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells |
| title_short | The Molecular Mechanism Underlying Continuous Exercise Training-Induced Adaptive Changes of Lipolysis in White Adipose Cells |
| title_sort | molecular mechanism underlying continuous exercise training induced adaptive changes of lipolysis in white adipose cells |
| url | http://dx.doi.org/10.1155/2015/473430 |
| work_keys_str_mv | AT junetsuogasawara themolecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT tetsuyaizawa themolecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT tomonobusakurai themolecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT takuyasakurai themolecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT kenshirato themolecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT yoshinagaishibashi themolecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT hitoshiishida themolecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT hidekiohno themolecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT takakokizaki themolecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT junetsuogasawara molecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT tetsuyaizawa molecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT tomonobusakurai molecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT takuyasakurai molecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT kenshirato molecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT yoshinagaishibashi molecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT hitoshiishida molecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT hidekiohno molecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells AT takakokizaki molecularmechanismunderlyingcontinuousexercisetraininginducedadaptivechangesoflipolysisinwhiteadiposecells |