Novel Expanding Renal Cell Carcinoma Biomarkers
Identification of reliable molecular biomarkers that can complement clinical practice represents a fascinating challenge in any cancer field. Renal tumors are usually asymptomatic and incidentally identified during imaging studies undertaken for unrelated causes. However, in 25% to 30%...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-01-01
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| Series: | Société Internationale d’Urologie Journal |
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| Online Access: | https://siuj.org/index.php/siuj/article/view/60/20 |
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| _version_ | 1850045636327505920 |
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| author | Francesco Claps, Maria Carmen Mir |
| author_facet | Francesco Claps, Maria Carmen Mir |
| author_sort | Francesco Claps, Maria Carmen Mir |
| collection | DOAJ |
| description | Identification of reliable molecular biomarkers that can complement clinical practice represents a fascinating challenge in any cancer field. Renal tumors are usually asymptomatic and incidentally identified during imaging studies undertaken for unrelated causes. However, in 25% to 30% of patients the first diagnosis is accompanied by symptoms and associated with distant metastasis. Thus, early diagnosis may reduce the risk of disease progression also avoiding side effects of inadequate treatments. Moreover, the ability to categorize patients' risk of recurrence after radical treatment, or even predict benefit from a target therapy, represents a compelling challenge. Here we review the current state-of-the-art on RCC biomarkers, particularly focusing on the new approaches of genomics, liquid biopsy, proteomics, and metabolomics. |
| format | Article |
| id | doaj-art-ddec07178188496b8d8c39daa0b00dba |
| institution | DOAJ |
| issn | 2563-6499 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Société Internationale d’Urologie Journal |
| spelling | doaj-art-ddec07178188496b8d8c39daa0b00dba2025-08-20T02:54:39ZengMDPI AGSociété Internationale d’Urologie Journal2563-64992021-01-0121324210.48083/XLQZ8269Novel Expanding Renal Cell Carcinoma BiomarkersFrancesco Claps, Maria Carmen MirIdentification of reliable molecular biomarkers that can complement clinical practice represents a fascinating challenge in any cancer field. Renal tumors are usually asymptomatic and incidentally identified during imaging studies undertaken for unrelated causes. However, in 25% to 30% of patients the first diagnosis is accompanied by symptoms and associated with distant metastasis. Thus, early diagnosis may reduce the risk of disease progression also avoiding side effects of inadequate treatments. Moreover, the ability to categorize patients' risk of recurrence after radical treatment, or even predict benefit from a target therapy, represents a compelling challenge. Here we review the current state-of-the-art on RCC biomarkers, particularly focusing on the new approaches of genomics, liquid biopsy, proteomics, and metabolomics.https://siuj.org/index.php/siuj/article/view/60/20renal cell carcinomabiomarkerdiagnosisprognosissurvival |
| spellingShingle | Francesco Claps, Maria Carmen Mir Novel Expanding Renal Cell Carcinoma Biomarkers Société Internationale d’Urologie Journal renal cell carcinoma biomarker diagnosis prognosis survival |
| title | Novel Expanding Renal Cell Carcinoma Biomarkers |
| title_full | Novel Expanding Renal Cell Carcinoma Biomarkers |
| title_fullStr | Novel Expanding Renal Cell Carcinoma Biomarkers |
| title_full_unstemmed | Novel Expanding Renal Cell Carcinoma Biomarkers |
| title_short | Novel Expanding Renal Cell Carcinoma Biomarkers |
| title_sort | novel expanding renal cell carcinoma biomarkers |
| topic | renal cell carcinoma biomarker diagnosis prognosis survival |
| url | https://siuj.org/index.php/siuj/article/view/60/20 |
| work_keys_str_mv | AT francescoclapsmariacarmenmir novelexpandingrenalcellcarcinomabiomarkers |